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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

LINE-1 hypomethylation is associated with poor risperidone response in a first episode of psychosis cohort

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Author(s):
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Marques, Diogo Ferri [1, 2, 3] ; Ota, Vanessa Kiyomi [2, 3] ; Santoro, Marcos Leite [1, 2, 3] ; Talarico, Fernanda [2, 3] ; Costa, Giovany Oliveira [2, 3] ; Spindola, Leticia Maria [1, 3] ; Cogo-Moreira, Hugo [3] ; Carvalho, Carolina Muniz [1, 2, 3] ; Xavier, Gabriela [2, 3] ; Cavalcante, Daniel Azevedo [1, 3] ; Gadelha, Ary [1, 3] ; Noto, Cristiano [1, 3] ; Cordeiro, Quirino [1, 4] ; Bressan, Rodrigo Affonseca [1, 3] ; Moretti, Patricia Natalia [5] ; Belangero, Sintia Iole [1, 2, 3]
Total Authors: 16
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Genet Div, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Lab Integrat Neurosci LiNC, Sao Paulo - Brazil
[4] Fac Ciencias Med Santa Casa Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[5] Univ Brasilia, Fac Med, Programa Posgrad Ciencias Med, Brasilia, DF - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Epigenomics; v. 12, n. 12 APR 2020.
Web of Science Citations: 0
Abstract

Aim:We investigated the DNA methylation profile over LINE-1 in antipsychotic-naive, first-episode psychosis-patients (n = 69) before and after 2 months of risperidone treatment and in healthy controls (n = 62).Materials \& methods:Patients were evaluated using standardized scales and classified as responders and nonresponders. DNA from blood was bisulfite converted and LINE-1 fragments were amplified and pyrosequencing was performed.Results:Lower LINE-1 methylation was observed in antipsychotic-naive first-episode psychosis patients than in healthy controls. Lower DNA methylation levels before treatment were associated with poor risperidone responses. A positive correlation was observed between LINE-1 methylation levels and positive symptoms response.Conclusion:Our study brings new insight regarding how epigenomic studies and clinical correlation studies can supplement psychosis treatment. (AU)

FAPESP's process: 16/04983-7 - Neuroimaging, genomics, transcriptomics and epigenomics: dealing with big data toward an integrative model of mental disorders
Grantee:Jair de Jesus Mari
Support type: Research Grants - eScience and Data Science Program - Regular Program Grants
FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/02246-5 - Investigation of the Brain Connectivity Patterns Associated with Psychotic Experiences Throughout Infancy and Adolescence and the genetic and environmental modulation
Grantee:Rodrigo Affonseca Bressan
Support type: Scholarships abroad - Research
FAPESP's process: 17/25016-8 - INVESTIGATION OF THE TREATMENT RESPONSE OF SCHIZOPHRENIA WITH RISPERIDONE: A PHARMACOGENETICS STUDY IN A COHORT OF FIRST EPISODE OF PSYCHOSIS PATIENTS
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants
FAPESP's process: 10/08968-6 - INVESTIGATION OF GENETIC AND EPIGENETIC MARKERS: A TRANSLATIONAL APPROACH FOR SCHIZOPHRENIA TREATMENT
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants
FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants