LINE-1 hypomethylation is associated with poor risperidone response in a first episode of psychosis cohort

Author(s):Show less -

Marques, Diogo Ferri ^{[1, 2, 3]} ; Ota, Vanessa Kiyomi ^{[2, 3]} ; Santoro, Marcos Leite ^{[1, 2, 3]} ; Talarico, Fernanda ^{[2, 3]} ; Costa, Giovany Oliveira ^{[2, 3]} ; Spindola, Leticia Maria ^{[1, 3]} ; Cogo-Moreira, Hugo ^[3] ; Carvalho, Carolina Muniz ^{[1, 2, 3]} ; Xavier, Gabriela ^{[2, 3]} ; Cavalcante, Daniel Azevedo ^{[1, 3]} ; Gadelha, Ary ^{[1, 3]} ; Noto, Cristiano ^{[1, 3]} ; Cordeiro, Quirino ^{[1, 4]} ; Bressan, Rodrigo Affonseca ^{[1, 3]} ; Moretti, Patricia Natalia ^[5] ; Belangero, Sintia Iole ^{[1, 2, 3]}

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Genet Div, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Lab Integrat Neurosci LiNC, Sao Paulo - Brazil

^[4] Fac Ciencias Med Santa Casa Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[5] Univ Brasilia, Fac Med, Programa Posgrad Ciencias Med, Brasilia, DF - Brazil

• Document type: Journal article
• Source: Epigenomics; v. 12, n. 12 APR 2020.
• Web of Science Citations: 0

Abstract

Aim:We investigated the DNA methylation profile over LINE-1 in antipsychotic-naive, first-episode psychosis-patients (n = 69) before and after 2 months of risperidone treatment and in healthy controls (n = 62).Materials \& methods:Patients were evaluated using standardized scales and classified as responders and nonresponders. DNA from blood was bisulfite converted and LINE-1 fragments were amplified and pyrosequencing was performed.Results:Lower LINE-1 methylation was observed in antipsychotic-naive first-episode psychosis patients than in healthy controls. Lower DNA methylation levels before treatment were associated with poor risperidone responses. A positive correlation was observed between LINE-1 methylation levels and positive symptoms response.Conclusion:Our study brings new insight regarding how epigenomic studies and clinical correlation studies can supplement psychosis treatment. (AU)

• FAPESP's process: 16/04983-7 - Neuroimaging, genomics, transcriptomics and epigenomics: dealing with big data toward an integrative model of mental disorders
• Grantee: Jair de Jesus Mari
• Support Opportunities: Research Grants - eScience and Data Science Program - Regular Program Grants
• FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/02246-5 - Investigation of the brain connectivity patterns associated with psychotic experiences throughout infancy and adolescence and the genetic and environmental modulation
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 17/25016-8 - Investigation of the treatment response of schizophrenia with risperidone: a pharmacogenetics study in a cohort of first episode of psychosis patients
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/08968-6 - Investigation of genetic and epigenetic markers: a translational approach for schizophrenia treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants