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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Application of experimental design to evaluate the incorporation of naproxen into sericin/alginate particles prepared by ionic gelation technique

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Author(s):
Freitas, E. D. [1] ; Rosa, P. C. P. [2] ; Silva, M. G. C. [1] ; Vieira, M. G. A. [1]
Total Authors: 4
Affiliation:
[1] Univ Campinas UNICAMP, Sch Chem Engn, Dept Proc & Prod Design, Albert Einstein Ave 500, BR-13083852 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Med Sci, Dept Pharmacol, Tessalia Vieira Camargo St, BR-13083887 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Chemical Engineering Science; v. 229, JAN 16 2021.
Web of Science Citations: 0
Abstract

The polymeric blend of sericin and alginate has already shown good results for the incorporation of naproxen, achieving delayed and prolonged release. Thus, in this paper, it was aimed to optimize formu-lations of naproxen-loaded sericin and alginate blend, using the technique of experimental design. Initial amounts of alginate and drug were evaluated on entrapment efficiency, drug loading and time to release 85% of drug (t(85)). Efficiency was not affected statistically, while drug loading was higher for higher amounts of naproxen. In addition, the longest release times were achieved for greater amounts of drug and/or alginate, and the presence of sericin proved to be essential to extend the release of naproxen. The analytical characterizations of the particles showed the incorporation of the drug mainly in its original crystalline form, with part being physically mixed with the matrix. In addition, both the matrix and the drug loaded matrix demonstrated biocompatibility with HaCaT cell line. (c) 2020 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/13505-9 - INCORPORATION AND RELEASE OF DRUGS BY SERICIN-ALGINATE MICROPARTICLES
Grantee:Melissa Gurgel Adeodato Vieira
Support Opportunities: Regular Research Grants
FAPESP's process: 16/05007-1 - Removal of residual drug in aqueous solution by alternative adsorbents
Grantee:Meuris Gurgel Carlos da Silva
Support Opportunities: Regular Research Grants