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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin

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Author(s):
de Farias, Aline Leite [1] ; Meneguin, Andreia Bagliotti [2] ; Barud, Hernane da Silva [3] ; Brighenti, Fernanda Lourencao [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Dent, Dept Morphol Pediat Dent & Orthodont, BR-14801903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14801903 Araraquara, SP - Brazil
[3] Univ Araraquara UNIARA, Biopolymers & Biomat Lab BioPolMat, R Carlos Gomes 1217, BR-14801340 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 162, p. 1944-1958, NOV 1 2020.
Web of Science Citations: 0
Abstract

The use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms. (C) 2020 Published by Elsevier B.V. (AU)

FAPESP's process: 13/12326-8 - Microbial interactions between cariogenic bacteria: evaluation of growth, metabolic activity, biochemical composition and susceptibility to chlorhexidine of biofilms formed in vitro
Grantee:Fernanda Lourenção Brighenti
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/25512-8 - Biocelulose-based Cell Culture Platform
Grantee:Hernane da Silva Barud
Support Opportunities: Regular Research Grants