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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rosettes integrity protects Plasmodium vivax of being phagocytized

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Author(s):
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Albrecht, Letusa [1, 2] ; Lopes, Stefanie C. P. [3, 4] ; Iung Enembreck da Silva, Ana Beatriz [1] ; Barbosa, Vanessa [3, 4] ; Almeida, Rodrigo P. [1] ; Siqueira, Andre M. [5] ; Leite, Juliana Almeida [2] ; Bittencourt, Najara C. [2] ; dos Santos, Hellen Geremias [1] ; Bourgard, Catarina [2] ; Cardoso Garcia, Luiz Fernando [1] ; Kayano, Ana Carolina A. V. [1, 2] ; Soares, Irene S. [6] ; Russell, Bruce [7] ; Renia, Laurent [8] ; Lacerda, Marcus V. G. [3, 4] ; Costa, Fabio T. M. [2]
Total Authors: 17
Affiliation:
[1] Fiocruz Parana, Inst Carlos Chagas, Lab Pesquisa Apicomplexa, Curitiba, Parana - Brazil
[2] Univ Estadual Campinas UNICAMP, Inst Biol, Dept Genet Evolucao Microbiol & Imunol, Lab Doencas Tropicais Prof Luiz Jacintho da Silva, Campinas, SP - Brazil
[3] Fundacao Med Trop Dr Heitor Vieira Dourado, Gerencia Malaria, Manaus, Amazonas - Brazil
[4] Fiocruz Amazonia, Inst Leonidas & Maria Deane, Manaus, Amazonas - Brazil
[5] Fiocruz MS, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, RJ - Brazil
[6] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, SP - Brazil
[7] Univ Otago, Dept Microbiol & Immunol, Dunedin - New Zealand
[8] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore - Singapore
Total Affiliations: 8
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 OCT 7 2020.
Web of Science Citations: 2
Abstract

Plasmodium vivax is the most prevalent cause of malaria outside of Africa. P. vivax biology and pathogenesis are still poorly understood. The role of one highly occurring phenotype in particular where infected reticulocytes cytoadhere to noninfected normocytes, forming rosettes, remains unknown. Here, using a range of ex vivo approaches, we showed that P. vivax rosetting rates were enhanced by plasma of infected patients and that total immunoglobulin M levels correlated with rosetting frequency. Moreover, rosetting rates were also correlated with parasitemia, IL-6 and IL-10 levels in infected patients. Transcriptomic analysis of peripheral leukocytes from P. vivax-infected patients with low or moderated rosetting rates identified differentially expressed genes related to human host phagocytosis pathway. In addition, phagocytosis assay showed that rosetting parasites were less phagocyted. Collectively, these results showed that rosette formation plays a role in host immune response by hampering leukocyte phagocytosis. Thus, these findings suggest that rosetting could be an effective P. vivax immune evasion strategy. (AU)

FAPESP's process: 13/20509-5 - Analyses of the immunopathological and molecular mechanisms involved in cytoadherence of Plasmodium vivax
Grantee:Catarina Baeta da Luz Bourgard
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity
Grantee:Fabio Trindade Maranhão Costa
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/25807-4 - Dissecting the mechanisms of infectivity in Plasmodium - Plasmodium yoelii experimental model with implications for the study in Plasmodium vivax.
Grantee:Juliana Almeida Leite
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/18611-7 - Development of new tools for search and validation of molecular targets for therapy against Plasmodium vivax
Grantee:Fabio Trindade Maranhão Costa
Support Opportunities: Research Projects - Thematic Grants