Emilio-Silva, Maycon T.
Rodrigues, Vinicius P.
Martins, Marina G.
Horta-Junior, Jose A. C.
Branco, Luiz G. S.
Rocha, Lucia R. M.
Hiruma-Lima, Clelia A.
Total Authors: 9
 Sao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol Physiol, BR-18618970 Botucatu, SP - Brazil
 Univ Sao Paulo, Inst Biosci, Dept Physiol, BR-05508090 Sao Paulo - Brazil
 Sao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol Anat, BR-18618689 Botucatu, SP - Brazil
 Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Basic & Oral Biol, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Web of Science Citations:
Citral is a mixture of monoterpenes present in the essential oil of several plants, such as Cymbopogon citratus and Zingiber officinale, possessing anti-inflammatory, anti-ulcerogenic, and antipyretic actions. We investigated the action of citral on body temperature (Tb) and inflammatory signaling in eutrophic and obese mice during Systemic Inflammation (SI) induced by Lipopolysaccharide (LPS). Thus, we assessed the effect of citral (25, 100, and 300 mg/kg) and ibuprofen in LPS-induced SI in Swiss male mice fed a standard diet (SD) or high-fat diet (HFD) for 12 weeks. Following SI induction, we measured Tb and collected the serum, hypothalamus, and gastric mucosa for biochemical measurements. Acute treatment with citral decreased the Tb of both SD and HFD-fed animals. Citral (300 mg/kg) treatment caused a significantly lower Tb variation in HFD-fed animals than in those fed the SD. Citral reduced peripheral levels of tumor necrosis factor (TNF)-alpha in SD and HFD mice and decreased serum leptin concentration in HFD mice 90 min after the LPS challenge. Furthermore, citral also reduced interleukin (IL)-6 levels in the hypothalamus of obese mice. In summary, citral effectively reduced Tb during SI by reducing inflammatory mediators with a distinct action profile in HFD mice when compared with SD. (AU)