Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

Full text
Author(s):
Show less -
Coelho, Barbara Paranhos [1] ; de Lima Fernandes, Camila Felix [1] ; Boccacino, Jacqueline Marcia [1] ; da Silva Souza, Maria Clara [1] ; Melo-Escobar, Maria Isabel [1] ; Alves, Rodrigo Nunes [1] ; Prado, Mariana Brandao [1] ; Iglesia, Rebeca Piatniczka [1] ; Cangiano, Giovanni [1] ; Mazzaro, Giulia La Rocca [1] ; Lopes, Marilene Hohmuth [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Lab Neurobiol & Stem Cells, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN ONCOLOGY; v. 10, NOV 12 2020.
Web of Science Citations: 0
Abstract

Tumor cells can employ epithelial-mesenchymal transition (EMT) or autophagy in reaction to microenvironmental stress. Importantly, EMT and autophagy negatively regulate each other, are able to interconvert, and both have been shown to contribute to drug-resistance in glioblastoma (GBM). EMT has been considered one of the mechanisms that confer invasive properties to GBM cells. Autophagy, on the other hand, may show dual roles as either a GBM-promoter or GBM-suppressor, depending on microenvironmental cues. The Wingless (WNT) signaling pathway regulates a plethora of developmental and biological processes such as cellular proliferation, adhesion and motility. As such, GBM demonstrates deregulation of WNT signaling in favor of tumor initiation, proliferation and invasion. In EMT, WNT signaling promotes induction and stabilization of different EMT activators. WNT activity also represses autophagy, while nutrient deprivation induces beta-catenin degradation via autophagic machinery. Due to the importance of the WNT pathway to GBM, and the role of WNT signaling in EMT and autophagy, in this review we highlight the effects of the WNT signaling in the regulation of both processes in GBM, and discuss how the crosstalk between EMT and autophagy may ultimately affect tumor biology. (AU)

FAPESP's process: 19/14552-1 - Analysis of differentially expressed genes in PRNPlow and PRNPhigh patient-derived glioblastoma stem cells
Grantee:Giulia La Rocca Mazzaro
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/14952-0 - Characterization of intracellular signaling pathways modulated by the cellular prion protein on stemness maintenance in glioblastoma stem cells
Grantee:Bárbara Paranhos Coelho
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/26158-0 - Prion protein as stem regulator in glioblastoma stem cells: its role in the formation and function of multiprotein signaling platforms
Grantee:Mariana Brandão Prado
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 20/04687-4 - The role of neural stem cells extracellular vesicles in the modulation of phenotype of PRNP low and PRNP high glioblastoma stem cells
Grantee:Rodrigo Nunes Alves
Support type: Scholarships in Brazil - Master
FAPESP's process: 19/06971-4 - Evaluation of pluripotency and self-renewal of murine embryonic stem cells with differential expression of STI1
Grantee:Maria Clara da Silva Souza
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/11097-1 - Modulation of the neural phenotype of glioblastoma stem cells by extracellular miRNA from NSCs
Grantee:Maria Isabel Melo Escobar
Support type: Scholarships in Brazil - Master
FAPESP's process: 19/12710-9 - Role of cellular prion protein in temozolomide resistance: emphasis on processes modulated by hypoxia
Grantee:Rebeca Piatniczka Iglesia
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 20/07450-5 - Evaluation of transcript levels of PrPc downstream targets and intracellular signaling pathways in glioblastoma stem cells
Grantee:Jacqueline Marcia Boccacino
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/15557-4 - Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy
Grantee:Marilene Hohmuth Lopes
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 19/14741-9 - Study of the role of STI1 and assotiated factors in the proteostasis network and pluripotency regulation
Grantee:Camila Felix de Lima Fernandes
Support type: Scholarships in Brazil - Doctorate (Direct)