The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis

Author(s)

Oliveira, Caio C. ^[1] ; Correia, Carlos Roque D. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, BR-13083970 Sao Paulo - Brazil

• Document type: Review article
• Source: CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY; v. 26, DEC 2020.
• Web of Science Citations: 1

Abstract

The palladium-catalyzed Heck arylation of olefins using arenediazonium salts, known as the Heck-Matsuda reaction, constitutes an effective, green, and sustainable way to synthesize functionalized aryl intermediates for organic synthesis. The present review highlights this strategy focusing on some selected examples from our laboratory. The examples include the substrate-directed arylation of olefins - covalent and noncovalent strategies - and their application in the total syntheses of many pharmacologically active compounds, commercial drugs, and/or functional compounds. (AU)

• FAPESP's process: 18/01669-5 - New quiral metal catalysts and their applications in asymmetric catalysis
• Grantee: Caio Costa Oliveira
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
• Grantee: Carlos Roque Duarte Correia
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC