Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease

Author(s)

Eysert, Fanny ^[1] ; Kinoshita, Paula Fernanda ^{[1, 2]} ; Mary, Arnaud ^[1] ; Vaillant-Beuchot, Loan ^[1] ; Checler, Frederic ^[1] ; Chami, Mounia ^[1]

Affiliation

^[1] Univ Cote dAzur, CNRS, INSERM, Lab Excellence DistAlz, Inst Mol & Cellular Pharma, F-06560 Valbonne - France

^[2] Univ Sao Paulo, Dept Pharmacol, Inst Ciencias Biomed, BR-05508900 Sao Paulo - Brazil

• Document type: Review article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 24 DEC 2020.
• Web of Science Citations: 1

Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative pathology characterized by a progressive decline of cognitive functions. Alteration of various signaling cascades affecting distinct subcellular compartment functions and their communication likely contribute to AD progression. Among others, the alteration of the physical association between the endoplasmic reticulum (ER) and mitochondria, also referred as mitochondria-associated membranes (MAMs), impacts various cellular housekeeping functions such as phospholipids-, glucose-, cholesterol-, and fatty-acid-metabolism, as well as calcium signaling, which are all altered in AD. Our review describes the physical and functional proteome crosstalk between the ER and mitochondria and highlights the contribution of distinct molecular components of MAMs to mitochondrial and ER dysfunctions in AD progression. We also discuss potential strategies targeting MAMs to improve mitochondria and ER functions in AD. (AU)

• FAPESP's process: 19/26084-2 - The role of alpha-Klotho in neuroinflammation in Alzheimer's disease
• Grantee: Paula Fernanda Kinoshita
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor