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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats

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Author(s):
Oliveira, Paula G. F. P. [1, 2] ; Coelho, Paulo G. [3, 2, 4, 5] ; Bergamo, Edmara T. P. [6] ; Witek, Lukasz [3, 7] ; Borges, Cristine A. [1] ; Bezerra, Fabio B. [1] ; Novaes, Jr., Arthur B. [1] ; Souza, Sergio L. S. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Av Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil
[2] NYU, Sch Med, Hansjorg Wyss Dept Plast Surg, New York, NY 10010 - USA
[3] NYU, Coll Dent, Dept Biomat & Biomimet, New York, NY 10010 - USA
[4] NYU, Tandon Sch Engn, Dept Mech, 433 1st Ave, 8th Floor, New York, NY 10010 - USA
[5] NYU, Tandon Sch Engn, Dept Aerosp Engn, 433 1st Ave, 8th Floor, New York, NY 10010 - USA
[6] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodontol, Av Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil
[7] NYU, Tandon Sch Engn, Dept Biomed Engn, 433 1st Ave, 8th Floor, New York, NY 10010 - USA
Total Affiliations: 7
Document type: Journal article
Source: MATERIALS; v. 13, n. 24 DEC 2020.
Web of Science Citations: 0
Abstract

Implant therapy is a predictable treatment to replace missing teeth. However, the osseointegration process may be negatively influenced by systemic conditions, such as diabetes mellitus (DM). Microtopography and implant surface developments are strategies associated to better bone repair. This study aimed to evaluate, in healthy and diabetic rats, histomorphometric (bone to implant contact = %BIC; and bone area fraction occupancy = %BAFO) and nanomechanical (elastic modulus = EM; and hardness = H) bone parameters, in response to a nanometric hydroxyapatite implant surface. Mini implants (machined = MAC; double acid etched = DAE, and with addition of nano-hydroxyapatite = NANO) were installed in tibias of healthy and diabetic rats. The animals were euthanized at 7 and 30 days. NANO surface presented higher %BIC and %BAFO when compared to MAC and DAE (data evaluated as a function of implant surface). NANO surface presented higher %BIC and %BAFO, with statistically significant differences (data as a function of time and implant surface). NANO surface depicted higher EM and H values, when compared to machined and DAE surfaces (data as a function of time and implant surface). Nano-hydroxyapatite coated implants presented promising biomechanical results and could be an important tool to compensate impaired bone healing reported in diabetics. (AU)

FAPESP's process: 16/14584-2 - Nanomechanical test of a new 4th generation implant surface, modified by the addition of nano-hydroxyapatite: in vivo study in diabetic rats
Grantee:Paula Gabriela Faciola Pessoa de Oliveira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/09879-0 - Evaluation of a new hydroxiapatite covered nanometric implant surface. An in vitro study in rats
Grantee:Paula Gabriela Faciola Pessoa de Oliveira
Support type: Scholarships in Brazil - Doctorate