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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice

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Author(s):
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Zhang, Zhi [1, 2] ; Reis, Fernando M. C. V. [3] ; He, Yanlin [4, 5] ; Park, Jae W. [1] ; DiVittorio, Johnathon R. [1] ; Sivakumar, Nilla [1] ; van Veen, J. Edward [1, 2] ; Maesta-Pereira, Sandra ; Shum, Michael [6, 7] ; Nichols, India [1] ; Massa, Megan G. [1, 2] ; Anderson, Shawn [1] ; Paul, Ketema [1] ; Liesa, Marc [6, 7] ; Ajijola, Olujimi A. [8] ; Xu, Yong ; Adhikari, Avishek [3, 2] ; Correa, Stephanie M. [1, 2]
Total Authors: 18
Affiliation:
[1] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 - USA
[2] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 - USA
[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA - USA
[4] Baylor Univ, Dept Pediat, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 - USA
[5] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 - USA
[6] David Geffen Sch Med, Dept Med, Div Endocrinol, Los Angeles, CA - USA
[7] David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA - USA
[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Cardiac Arrhythmia Ctr, Los Angeles, CA 90095 - USA
Total Affiliations: 8
Document type: Journal article
Source: NATURE COMMUNICATIONS; v. 11, n. 1 DEC 11 2020.
Web of Science Citations: 1
Abstract

Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The MPA is estrogen-sensitive and estrogens also have potent effects on both temperature and metabolism. Here, we demonstrate that estrogen-sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice. Selectively activating estrogen-sensitive MPA neurons was sufficient to drive a coordinated depression of metabolic rate and body temperature similar to torpor, as measured by body temperature, physical activity, indirect calorimetry, heart rate, and brain activity. Inducing torpor with a prolonged fast revealed larger and more variable calcium transients from estrogen-sensitive MPA neurons during bouts of hypothermia. Finally, whereas selective ablation of estrogen-sensitive MPA neurons demonstrated that these neurons are required for the full expression of fasting-induced torpor in both female and male mice, their effects on thermoregulation and torpor bout initiation exhibit differences across sex. Together, these findings suggest a role for estrogen-sensitive MPA neurons in directing the thermoregulatory and metabolic responses to energy deficiency. Torpor is a state of reduced metabolism and body temperature that conserves energy when food is scarce. Here the authors show that estrogen-sensitive neurons in the hypothalamus regulate torpor in mice, maintaining torpor in both sexes but initiating torpor and regulating core temperature differentially across sex. (AU)

FAPESP's process: 17/08668-1 - In vivo study of GABAergic and glutamatergic neuronal populations of the periaqueductal gray matter in response to different kinds of threat
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 15/23092-3 - Signaling pathways involved in fear memory to predatory threats
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Support type: Scholarships in Brazil - Post-Doctorate