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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Batzelladine D and norbatzelladine L purified from marine sponge Monanchora arbuscula induce the reversal of fluconazole

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Author(s):
Domingos, Levy T. S. [1] ; Santos, Mario F. C. [2] ; de Moraes, Daniel C. [1] ; de Sa, Leandro F. R. [1] ; da Silva, Vinicius A. D. [1] ; Meuren, Lana M. [3] ; Berlinck, Roberto G. S. [2] ; Ferreira-Pereira, Antonio [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Rio de Janeiro, Dept Microbiol Geral, Lab Bioquim Microbiana, IMPG, Bloco I S-44, BR-21949900 Rio De Janeiro, RJ - Brazil
[2] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[3] Univ Fed Rio de Janeiro, IMPG, Dept Virol, BR-21949900 Rio De Janeiro, RJ - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BIOORGANIC CHEMISTRY; v. 105, DEC 2020.
Web of Science Citations: 0
Abstract

ATP-Binding Cassette (ABC) transporters are the main class of transmembrane transporters involved in pathogenic fungal resistance against chemotherapeutic agents. Herein we report results which show that batzelladine D (1) and norbatzelladine L (2) reverse the fluconazole resistance phenotype mediated by Pdr5p transporter on Saccharomyces cerevisiae. Both alkaloids were able to chemosensitize the Pdr5p-overexpressing strain by synergistic interaction with fluconazole. Both compounds also showed an inhibitory effect on the catalytic activity and on the intracellular accumulation of rhodamine 6G, and did not show significant in vitro mammalian cells toxicity. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants