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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells

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Author(s):
Graminha, Angelica E. [1, 2] ; Honorato, Joao [1] ; Correa, Rodrigo S. [3] ; Cominetti, Marcia R. [2] ; Menezes, Antonio C. S. [4] ; Batista, Alzir A. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos UFSCar, Dept Quim, Rodovia Washington Luis Km 235, CP 676, BR-13561001 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos UFSCar, Dept Gerontol, Rodovia Washington Luis Km 235, CP 676, BR-13561901 Sao Carlos, SP - Brazil
[3] Univ Fed Ouro Preto UFOP, Dept Quim, BR-35400000 Ouro Preto, MG - Brazil
[4] Univ Estadual Goias UEG, Ctr Ciencias Exatas & Tecnol, BR 153, CP 459, BR-75132903 Anapolis, Go - Brazil
Total Affiliations: 4
Document type: Journal article
Source: DALTON TRANSACTIONS; v. 50, n. 1, p. 323-335, JAN 7 2021.
Web of Science Citations: 0
Abstract

This work describes the synthesis of three new ruthenium(II) complexes with gallic acid and derivatives of the general formula {[}Ru(L)(dppb)(bipy)]PF6, where L = gallate (GAC), benzoate (BAC), and esterified-gallate (EGA), bipy = 2,2 `-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane. The complexes were characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV-vis and IR spectroscopy, and two of them by X-ray crystallography. Cell viability assays show promising results, indicating higher cytotoxicity of the complexes in MDA-MB-231 cells, a triple-negative breast cancer (TNBC) cell line, compared with the hormone-dependent MCF-7 cell line. Studies in vitro with the MDA-MB-231 cell line showed that only Ru(BAC) and Ru(GAC) interacted with BSA. Besides that, the Ru(GAC) complex, which has a polyphenolic acid, interacted in an apo-Tf structure and function dependent manner and it was able to inhibit the formation of reactive oxygen species. Ru(GAC) was able to cause damage to the cellular cytoskeleton leading to inhibition of some cellular processes of TNBC cells, such as invasion, migration, and adhesion. (AU)

FAPESP's process: 16/16312-0 - CYTOTOXICITY AND MECHANISM OF ACTION OF RUTHENIUM COMPLEXES CONTAINING NATURAL PRODUCTS OR DERIVATIVES
Grantee:Alzir Azevedo Batista
Support type: Regular Research Grants
FAPESP's process: 15/24940-8 - EFFECTIVENESS OF STRUCTURAL CHANGES IN [10]-GINGEROL MOLECULE IN COMBINATION WITH THE CHEMOTHERAPEUTIC DOXORUBICIN FOR THE TREATMENT OF BREAST CANCER: IN VITRO AND IN VIVO STUDIES. ABSTRACT
Grantee:Márcia Regina Cominetti
Support type: Regular Research Grants
FAPESP's process: 14/19632-0 - New ruthenium complexes with bioactive ligands: investigation of the mechanismo of action
Grantee:Angelica Ellen Graminha
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC