Birth weight associated with dual energy X-ray absorptiometry-determined muscle-bone unit in young healthy women from the Nutritionists' Health Study

Author(s)

Valente, Angelica Marques Martins ^[1] ; de Almeida-Pititto, Bianca ^[2] ; Archanjo Ferraro, Alexandre ^[3] ; Dias Folchetti, Luciana G. ^[1] ; Tande Silva, Isis ^[1] ; Ferreira, Sandra Roberta G. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Med Sch, Dept Pediat, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE; v. 12, n. 1, p. 42-49, FEB 2021.
• Web of Science Citations: 0

Abstract

Muscle and bone have been considered a functional unit that grows together early in life, deteriorates with aging, and can cause osteosarcopenia. Due to its importance in public health, detecting risk factors in early life is desirable. This study examined whether birth weight (BW) was associated with muscle-bone unit using dual energy X-ray absorptiometry (DXA) parameters in young women from the Nutritionists' Health Study (NutriHS), a cohort study of undergraduates and Nutrition graduates. This cross-sectional analysis included 170 young healthy women who answered early life events-questionnaire, and had anthropometric, muscle tests and DXA-determined body composition and bone densitometry (iDXA-Lunar (R)). A blood sample was obtained for a subsample of 148 participants. Appendicular skeletal muscle mass index (ASMI) was calculated. BW was categorized in quartiles (BWq) and variables of interest compared by ANOVA. Associations of BWq with calf circumference (CC), handgrip, muscle performance tests, ASMI, bone mineral density and content (BMD and BMC), and plasma glucose, lipids, insulin, and 25-hydroxyvitamin D were performed using multiple linear regression and directed acyclic graph-recommended adjustments. Mean values of age, body mass index, and BW were 23.0 years (20.0-28.0), 22.9 +/- 2.9 kg/m(2), and 3199 +/- 424 g, respectively. Comparing variables across BWq, significant differences in CC, handgrip, ASMI, and total body BMC were detected. Regression models adjusted for confounders showed associations of BWq with CC (beta = 0.72, p = 0.005), handgrip (beta = 1.53, p = 0.001), ASMI (beta = 0.16, p = 0.022), total body BMC (beta = 64.8, p = 0.005), total femur BMC (beta = 0.70, p = 0.041), total body BMD (beta = 0.02, p = 0.043), and lumbar spine BMD (beta = 0.03, p = 0.028). We conclude that BW is associated with muscle-bone unit using DXA-parameters in Brazilian young healthy women from the NutriHS, suggesting a role for intrauterine environment for musculoskeletal health. (AU)

• FAPESP's process: 15/10045-7 - Interelationship of body composition and early factors in lifespan in the Nutritionist Health Study: modulation by gut microbiota?
• Grantee: Sandra Roberta Gouvea Ferreira Vivolo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/13087-8 - Breastfeeding and other early life events and its association with dietary patterns, body composition e cardiometabolic profile during adult life
• Grantee: Ilana Eshriqui Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate