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Metabolic phenotypes of obesity: associations with short chain fatty acids and components of energy and glycemic homeostasis in the Nutritionists Health Study - NutriHS

Abstract

Obesity is a multifactorial disease that presents different phenotypes. There are metabolically healthy obese (MHO), obese metabolically obese (OMO), and lean metabolically obese (LMO). The mechanisms that explain the development and maintenance of each phenotype are not fully elucidated. Individuals with increased energy flow and metabolic flexibility appear to be protected from weight gain and type 2 diabetes. Evidence suggests that the intestinal microbiota modulates energy and glycemic homeostasis via short chain fatty acid production (SCFA). These findings open the opportunity for research into mechanisms that favor weight gain and diabetes development. The objective of this study is to compare the plasma SCFA profile and the energy and glycemic homeostasis components in four groups of women with the phenotypes: lean metabolic healthy, LMO, MHO and OMO. This is a cross-sectional study within the Nutritionists Health Study. We will study 120 adult women in four groups of 30 individuals. Evaluations will include life habits, anthropometry, body composition; and plasma lipid, inflammatory and glycemic profiles. The components of energy (metabolic flexibility, energy flow, oxidation of energetic substrates) and glycemic homeostasis (insulin sensitivity, insulin secretion and incretins) will be evaluated by indirect calorimetry associated with the standard meal test; with the following determinations: glucose, insulin, peptide C, GLP-1 and AGCC. It is expected to understand to what extent each phenotype can be explained by variations in the parameters evaluated. The relevance lies in the possibility of bringing a new therapeutic focus of research to the management of obesity, defining risk conditions, and providing subsidies to plan interventions. (AU)

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