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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroproteomics in Epilepsy: What Do We Know so Far?

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Author(s):
do Canto, Amanda M. [1, 2] ; Donatti, Amanda [1, 2] ; Geraldis, Jaqueline C. [1, 2] ; Godoi, Alexandre B. [1, 2] ; da Rosa, Douglas C. [1, 2] ; Lopes-Cendes, Iscia [1, 2]
Total Authors: 6
Affiliation:
[1] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas - Brazil
[2] Univ Campinas UNICAMP, Sch Med Sci, Dept Med Genet & Genom Med, Campinas - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN MOLECULAR NEUROSCIENCE; v. 13, JAN 7 2021.
Web of Science Citations: 0
Abstract

Epilepsies are chronic neurological diseases that affect approximately 2% of the world population. In addition to being one of the most frequent neurological disorders, treatment for patients with epilepsy remains a challenge, because a proportion of patients do not respond to the antiseizure medications that are currently available. This results in a severe economic and social burden for patients, families, and the healthcare system. A characteristic common to all forms of epilepsy is the occurrence of epileptic seizures that are caused by abnormal neuronal discharges, leading to a clinical manifestation that is dependent on the affected brain region. It is generally accepted that an imbalance between neuronal excitation and inhibition generates the synchronic electrical activity leading to seizures. However, it is still unclear how a normal neural circuit becomes susceptible to the generation of seizures or how epileptogenesis is induced. Herein, we review the results of recent proteomic studies applied to investigate the underlying mechanisms leading to epilepsies and how these findings may impact research and treatment for these disorders. (AU)

FAPESP's process: 15/12960-4 - Proteomic analysis of hippocampal tissues obtained from patients and animal model of Mesial Temporal Lobe Epilepsy: a comparative study
Grantee:Amanda Morato Do Canto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/00048-0 - Metabolic profile of patients with ischemic strokes: research for biomarkers
Grantee:Douglas Cescon da Rosa
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
Grantee:Fernando Cendes
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 17/23954-0 - Methylation pattern of Genomic DNA in mesial temporal lobe epilepsy associated with hippocampal sclerosis
Grantee:Jaqueline Cruz Geraldis
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/25607-0 - Identification of Rare Genomic Variants and microRNAs expression patterns in stroke patients
Grantee:Amanda Donatti
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/00213-0 - Metabolomic analysis from plasma of patients with mesial temporal lobe epilepsy: searching for drug resistant biomarkers
Grantee:Alexandre Barcia de Godoi
Support Opportunities: Scholarships in Brazil - Scientific Initiation