Investigation of Copaifera genus as a new source of antimycobaterial agents

Author(s)

Alves, Jessica Aparecida ^[1] ; Abrao, Fariza ^[1] ; Moraes, Thais da Silva ^[1] ; Damasceno, Jaqueline Lopes ^[1] ; dos Santos Moraes, Marcos Fernando ^[2] ; Sola Veneziani, Rodrigo Cassio ^[2] ; Ambrosio, Sergio Ricardo ^[2] ; Bastos, Jairo Kenupp ^[3] ; Dantas Miranda, Mayker Lazaro ^[4] ; Gomes Martins, Carlos Henrique ^{[1, 5]}

Affiliation

^[1] Univ Franca, Res Lab Appl Microbiol, Franca, SP - Brazil

^[2] Univ Franca, Nucleus Res Sci & Technol, Franca, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[4] Fed Inst Educ Sci & Technol Triangulo Mineiro, Uberlandia, MG - Brazil

^[5] Univ Fed Uberlandia, Lab Res Antimicrobial Trials LaPEA, Inst Biomed Sci ICBIM, Uberlandia, MG - Brazil

• Document type: Journal article
• Source: FUTURE SCIENCE OA; v. 6, n. 7 AUG 2020.
• Web of Science Citations: 0

Abstract

Aim: This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. Materials \& methods: The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis. Results \& conclusion: Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values. Lay abstract: The purpose of this paper was to evaluate the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. against a panel of bacteria capable of causing tuberculosis. After completion of the experiments we concluded that oleoresins are better antimicrobial agents than extracts against evaluated bacteria and may represent a future source for the discovery of new antimycobacterial drugs. (AU)

• FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
• Grantee: Jairo Kenupp Bastos
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 12/25237-0 - Kaurane-type diterpenes: activity against anaerobic bacteria and proteomics
• Grantee: Carlos Henrique Gomes Martins
• Support Opportunities: Regular Research Grants