Dynamic changes in white matter following traumatic brain injury and how diffuse axonal injury relates to cognitive domain

Author(s)

Grassi, Daphine Centola ^{[1, 2]} ; Zaninotto, Ana Luiza ^{[3, 4]} ; Feltrin, Fabricio Stewan ^{[1, 2, 5]} ; Macruz, Fabiola Bezerra Carvalho ^{[1, 2]} ; Otaduy, Maria Concepcion Garcia ^{[1, 2]} ; Leite, Claudia Costa ^{[1, 2]} ; Guirado, Vinicius Monteiro Paula ^[3] ; Paiva, Wellingson Silva ^[3] ; Santos Andrade, Celi ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Fac Med, Dept Radiol, Av Dr Eneas De Carvalho Aguiar 255, BR-05403001 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Med Invest 44, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Neurol, Sao Paulo - Brazil

^[4] MGH Inst Hlth Profess MGHIHP, Speech & Feeding Disorders Lab, Boston, MA - USA

^[5] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX - USA

• Document type: Journal article
• Source: BRAIN INJURY; v. 35, n. 3 JAN 2021.
• Web of Science Citations: 0

Abstract

Objective: The goal is to evaluate longitudinally with diffusion tensor imaging (DTI) the integrity of cerebral white matter in patients with moderate and severe DAI and to correlate the DTI findings with cognitive deficits. Methods: Patients with DAI (n = 20) were scanned at three timepoints (2, 6 and 12 months) after trauma. A healthy control group (n = 20) was evaluated once with the same high-field MRI scanner. The corpus callosum (CC) and the bilateral superior longitudinal fascicles (SLFs) were assessed by deterministic tractography with ExploreDTI. A neuropschychological evaluation was also performed. Results: The CC and both SLFs demonstrated various microstructural abnormalities in between-groups comparisons. All DTI parameters demonstrated changes across time in the body of the CC, while FA (fractional anisotropy) increases were seen on both SLFs. In the splenium of the CC, progressive changes in the mean diffusivity (MD) and axial diffusivity (AD) were also observed. There was an improvement in attention and memory along time. Remarkably, DTI parameters demonstrated several correlations with the cognitive domains. Conclusions: Our findings suggest that microstructural changes in the white matter are dynamic and may be detectable by DTI throughout the first year after trauma. Likewise, patients also demonstrated improvement in some cognitive skills. (AU)

• FAPESP's process: 17/17065-9 - Longitudinal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury
• Grantee: Daphine Centola Grassi
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 16/05547-6 - Longitudinal multimodal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury
• Grantee: Celi Santos Andrade
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 15/18136-1 - Longitudinal multimodal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury
• Grantee: Celi Santos Andrade
• Support Opportunities: Research Grants - Young Investigators Grants