Short-Term Combined Exercise Improves Inflammatory Profile in the Retina of Obese Mice

Author(s):Show less -

Pereira de Campos, Thais Dantis ^{[1, 2]} ; da Cruz Rodrigues, Kellen Cristina ^{[1, 2]} ; Pereira, Rodrigo Martins ^{[1, 2]} ; Morelli, Ana Paula ^[3] ; da Rocha, Alisson Luiz ^[4] ; Canciglieri, Raphael dos Santos ^{[1, 2]} ; Ramos da Silva, Adelino Sanchez ^[4] ; Ropelle, Eduardo Rochete ^{[1, 2]} ; Pauli, Jose Rodrigo ^{[1, 2]} ; Simabuco, Fernando Moreira ^[3] ; Cintra, Dennys Esper ^[5] ; de Moura, Leandro Pereira ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Sch Appl Sci, Exercise Celular Biol Lab, BR-13484350 Limeira - Brazil

^[2] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise, BR-13484350 Limeira - Brazil

^[3] Univ Estadual Campinas, Multidisciplinary Lab Food & Hlth, Fac Appl Sci, BR-13484350 Limeira - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14030680 Ribeirao Preto - Brazil

^[5] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom, BR-13484350 Limeira - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 17 SEP 2020.
• Web of Science Citations: 0

Abstract

Excess of adipose tissue increases the concentration of proinflammatory cytokines, triggering a subclinical inflammatory condition. This inflammatory profile contributes to retina damage, which can lead to retinal dysfunction and reduced vision. Regularly practicing both aerobic and strength exercises is well known for promoting anti-inflammatory effects on different organs in the peripheral and central regions. However, the effects of combined physical exercise (CPE; strength + aerobic) on the inflammatory process in the retina tissue are not yet known. This study aimed to investigate the effects of CPE on the inflammatory profile of the retina in obese mice. Swiss mice were distributed into control, sedentary obese, and trained obese groups. The trained obese group was subjected to short-term CPE, 1 h/day, for 7 days. The CPE was composed of aerobic and strength exercises in the same exercise session. The strength exercise protocol consisted of 10 climbing series, with 12 +/- 1 dynamic climbing movements at 70% of the maximum voluntary carrying capacity (MVCC), and the aerobic exercise protocol consisted of 30 min of treadmill running, with an intensity of 75% of the exhaust velocity. Subsequently, the retina was excised and analyzed by Western blot. Obese animals presented impairment on glucose homeostasis and elevated levels of proinflammatory proteins in the serum and retina; however, CPE was effective in reversing these parameters, independently of changes in body adiposity. Therefore, for the first time, we have shown that short-term CPE can be an important strategy to treat an inflammatory profile in the retina. (AU)

• FAPESP's process: 15/07199-2 - Role of clusterin/ApoJ on insulin signalling in response to physical exercise in rodents and humans
• Grantee: Leandro Pereira de Moura
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/06833-8 - Could physical exercise improve visual acuity? Effects of different physical training protocols on tear composition and clusterin/ApoJ metabolism in the retina of obese rodent
• Grantee: Thaís Dantis Pereira de Campos
• Support Opportunities: Scholarships in Brazil - Master