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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Notch signaling pathway in infectious diseases: role in the regulation of immune response

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Author(s):
Castro, Ricardo Cardoso [1, 2] ; Goncales, Relber Aguiar [3] ; Zambuzi, Fabiana Albani [2] ; Frantz, Fabiani Gai [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, FMRP USP, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo FCFRP USP, Sch Pharmaceut Sci Ribeirao Preto, Immunol & Epigenet Lab, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Univ Minho, Life & Hlth Sci Res Inst, Sch Hlth Sci, Braga - Portugal
Total Affiliations: 3
Document type: Review article
Source: Inflammation Research; v. 70, n. 3 FEB 2021.
Web of Science Citations: 0
Abstract

Background The Notch signaling pathway is a cell signaling system that is conserved in a variety of eukaryotes. Overall, Notch receptors and their ligands are single-pass transmembrane proteins, which often require cell-cell interactions and proteolytic processing to promote signaling. Since its discovery, it has been the subject of extensive research that revealed its importance in several cellular mechanisms, including cell fate determination, hematopoiesis, tissue self-renewal, proliferation, and apoptosis during embryogenesis. Many studies have described the influence of the Notch pathway in modulating the innate and adaptive immune systems. Methods We analyzed the literature on the role of the Notch pathway in regulating immune responses during infections, aiming to discuss the importance of establishing a Notch signaling pathway-based approach for predicting the outcome of infectious diseases. Conclusion In this review, we present an overview of evidence that demonstrates the direct and indirect effects of interaction between the Notch signaling pathway and the immune responses against bacterial, viral, fungal, and parasitic infections, as well as the importance of this pathway to predict the outcome of infectious diseases. (AU)

FAPESP's process: 18/15066-0 - Epigenetic programming during chronic infectious diseases: tiring out and training the innate immune system
Grantee:Fabiani Gai Frantz
Support Opportunities: Research Grants - Young Investigators Grants - Phase 2