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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

One Bout of Aerobic Exercise Can Enhance the Expression of Nr1d1 in Oxidative Skeletal Muscle Samples

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Author(s):
Rovina, Rafael L. [1] ; da Rocha, Alisson L. [2] ; Marafon, Bruno B. [1] ; Pauli, Jose R. [3] ; de Moura, Leandro P. [3] ; Cintra, Dennys E. [3] ; Ropelle, Eduardo R. [3] ; da Silva, Adelino S. R. [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto - Brazil
[3] Univ Campinas UNICAMP, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, Limeira - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, FEB 1 2021.
Web of Science Citations: 0
Abstract

The nuclear receptor subfamily 1, group D member 1 (Nr1d1), plays a role in the skeletal muscle's oxidative capacity, mitochondrial biogenesis, atrophy genes, and muscle fiber size. In light of the effects of physical exercise, the present study investigates the acute response of Nr1d1 and genes related to atrophy and mitochondrial biogenesis on endurance and resistance exercise protocols. In this investigation, we observed, after one bout of endurance exercise, an upregulation of Nr1d1 in soleus muscle, but not in the gastrocnemius, and some genes related to mitochondrial biogenesis and atrophy were enhanced as well. Also, analysis of muscle transcripts from diverse isogenic BXD mice families revealed that the strains with higher Nr1d1 gene expression displayed upregulation of AMPK signaling and mitochondrial-related genes. In summary, a single session of endurance exercise can enhance the Nr1d1 mRNA levels in an oxidative muscle. (AU)

FAPESP's process: 17/12765-2 - Emerging role of rev-erb-alpha in molecular adaptations to different physical exercise models
Grantee:Alisson Luiz da Rocha
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/12519-4 - Response of NR1D1 to the different acute physical exercise models in mice skeletal muscle
Grantee:Rafael Lemes Rovina
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/09038-1 - EFFECTS OF REGULAR PHYSICAL EXERCISE AND OVERTRAINING ON THE BEHAVIOR OF THE AUTOPHAGIC PATHWAY IN DIFFERENT TISSUES OF MICE.
Grantee:Adelino Sanchez Ramos da Silva
Support Opportunities: Regular Research Grants