Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks

Author(s)

Faria, Alessandra V. S. ^{[1, 2]} ; Fonseca, Emanuella Maria Barreto ^{[1, 3]} ; Cordeiro, Helon Guimaraes ^[1] ; Clerici, Stefano Piatto ^[1] ; Ferreira-Halder, Carmen Verissima ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Campinas, SP - Brazil

^[2] Erasmus Univ, Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam - Netherlands

^[3] Fed Inst Sao Paulo, Sao Roque, SP - Brazil

• Document type: Review article
• Source: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 78, n. 4, p. 1263-1273, FEB 2021.
• Web of Science Citations: 0

Abstract

In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer. (AU)

• FAPESP's process: 17/08119-8 - Hematogenous tumor metastasis in colon rectal cancer cells: influence of LMWPTP and 3-bromopyruvate
• Grantee: Alessandra Valéria de Sousa Faria
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/11433-0 - 3-bromopyruvate as molecular tool to uncover the biological basis of protein phosphatase LMWPTP contribution to leukemic cells resistance
• Grantee: Emanuella Maria Barreto Fonseca
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/03593-6 - Tumor-educated platelets and metastasis: relevance of LMWPTP and extracellular vesicles in Colorectal Cancer
• Grantee: Stefano Piatto Clerici
• Support Opportunities: Scholarships in Brazil - Doctorate