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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development

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Author(s):
Scarini, Joao Figueira [1, 2] ; Abu Egal, Erika Said [1, 3] ; de Lima-Souza, Reydson Alcides [1, 2] ; Crescencio, Livia Ramalho [1, 2] ; Emerick, Carolina [2] ; Kowalski, Luiz Paulo [4] ; Altemani, Albina [1] ; Mariano, Fernanda Viviane [1]
Total Authors: 8
Affiliation:
[1] Univ Campinas UNICAMP, Fac Med Sci, Dept Pathol, Campinas, SP - Brazil
[2] Univ Campinas FOP UNICAMP, Sch Dent, Dept Oral Diag, Piracicaba, SP - Brazil
[3] Univ Utah UU, Sch Med, Dept Pathol, Salt Lake City, UT - USA
[4] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; v. 157, JAN 2021.
Web of Science Citations: 0
Abstract

The myoepithelial cell seems to play an important role as a tumor suppressor in the development of carcinoma ex pleomorphic adenoma. Nevertheless, interesting aspects concerning the other side of the coin, i.e., the contribution of the myoepithelial cell to cell proliferation, were brought to light. Here we highlighted the studies in which myoepithelial cells were presented as tumor suppressors and promoters in the context of PA malignant transformation. In conclusion, even if in a paracrine way, divergent signals can alter the suppressor role of the myoepithelial cell and induce it to compose a microenvironment propitious to the tumor progression of the malignant cells. This would cause myoepithelial cells to succumb and malignant epithelial cells to initiate progression beyond the basal membrane. (AU)

FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
Grantee:Fernanda Viviane Mariano Brum Corrêa
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/00831-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
Grantee:Fernanda Viviane Mariano Brum Corrêa
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 17/13167-1 - Study of metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by immuno-histochemistry
Grantee:Larissa Fernandes Rosa
Support Opportunities: Scholarships in Brazil - Scientific Initiation