Aerobic or resistance training improves autonomic control of circulation in oophorectomized rats with cardiometabolic dysfunctions: Impact on renal oxidative stress

Author(s)

Brito-Monzani, Janaina de Oliveira ^{[1, 2]} ; Stoyell-Conti, Filipe Fernandes ^{[2, 3]} ; Shecaira, Tania Plens ^{[2, 4]} ; Silva, Michel Pablo dos Santos Ferreira ^[2] ; Dias, Danielle da Silva ^{[2, 4]} ; Bernardes, Nathalia ^{[2, 5]} ; De Angelis, Katia ^{[2, 4]}

Affiliation

^[1] Fed Univ Maranhao UFMA, Sao Luis, Maranhao - Brazil

^[2] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo - Brazil

^[3] Univ Miami, Dept Surg, Miami, FL - USA

^[4] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Rua Botucatu, 862, Edificio Ciencias Biomed, 5 Andar, BR-04023062 Sao Paulo, SP - Brazil

^[5] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Experimental Gerontology; v. 145, MAR 2021.
• Web of Science Citations: 0

Abstract

Cardiovascular autonomic dysfunction is associated with end organ damage and increased risk of mortality. Menopause and metabolic syndrome increase the risk for cardiorenal complications. In this study, we investigated the effects of aerobic or resistance exercise training on autonomic control of circulation and renal oxidative stress in a model of menopause and metabolic syndrome. Female Wistar rats and spontaneously hypertensive rats (SHR) were divided into 5 groups (n = 8): control (C), hypertensive (H), and sedentary (FHO), aerobic trained (FHOTa) and resistance trained (FHOTr) oophorectomized hypertensive treated with fructose (100 mg/mL drink water for 19 weeks). The FHO group presented increased vascular sympathetic modulation (LF-SBP), impaired baroreflex sensitivity (BRS) associated with increased blood pressure (BP) when compared to the H group. Aerobic exercise training enhanced tachycardic responses, while resistance training improved bradycardic responses to BP changes, thus ameliorating BRS. Moreover, despite unchanged BP, both exercise training protocols were effective in preventing increase in LF-SBP, reduction in systemic nitric oxide bioavailability (NOx), and increase in oxidative stress in the renal tissue, by decreasing lipid and protein oxidation in renal tissue. Positive correlation between LF-SBP and renal lipoperoxidation (r = 0.63, p < 0.05), as well as a negative correlation between NOx and renal lipoperoxidation (r = -0.66, p < 0.05) were observed. In conclusion, both aerobic and resistance exercise training were effective in improving autonomic control of circulation and reducing renal oxidative stress, thus attenuating the deleterious effects induced by arterial hypertension and fructose overload in female rats after ovarian hormone deprivation. (AU)

• FAPESP's process: 18/17183-4 - Fructose overload in genitors: impact of exercise training on cardiometabolic and neuroimmune changes in offspring
• Grantee: Kátia de Angelis Lobo D Avila
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/20141-5 - Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation
• Grantee: Kátia de Angelis Lobo D Avila
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
• Grantee: Janaina de Oliveira Brito
• Support Opportunities: Scholarships in Brazil - Doctorate