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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation

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Madrid, Rafael R. M. [1] ; Mathews, Patrick D. [1] ; Patta, Ana C. M. F. [1] ; Gonzales-Flores, Anai P. [2, 3] ; Ramirez, Carlos A. B. [1] ; Rigoni, Vera L. S. [1] ; Tavares-Dias, Marcos [4] ; Mertins, Omar [1]
Total Authors: 8
[1] Fed Univ Sao Paulo UNIFESP, Paulista Med Sch, Dept Biophys, Lab Nano Bio Mat LNBM, BR-04023062 Sao Paulo, SP - Brazil
[2] Univ Fed Amapa, Postgrad Program Trop Biodivers, BR-68903419 Macapa, AP - Brazil
[3] AQUAREC, Inst Res Peruvian Amazon IIAP, Puerto Maldonado 17000 - Peru
[4] Embrapa Amapa, BR-68903419 Macapa, AP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: HELIYON; v. 7, n. 1 JAN 2021.
Web of Science Citations: 1

The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anti-cancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22-170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. (AU)

FAPESP's process: 15/23948-5 - Improvement of the polysaccharide chitosan properties for its application in liposomes and giant vesicles
Grantee:Omar Mertins
Support type: Regular Research Grants
FAPESP's process: 16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives
Grantee:Karin Do Amaral Riske
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/16722-6 - pH responsive nanoparticles for optimization of oral delivery of antiparasite drugs in the treatment of ornamental fish
Grantee:Ana Carolina Monge Fernandes Patta
Support type: Scholarships in Brazil - Master
FAPESP's process: 18/20482-3 - Diversity of microscopic cnidarians from the Amazon Basin with emphasis on phylogeny, systematic and interaction with their hosts
Grantee:Patrick Mathews Delgado
Support type: Scholarships in Brazil - Post-Doctorate