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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bone Regeneration Assessment of Polycaprolactone Membrane on Critical-Size Defects in Rat Calvaria

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Farnezi Bassi, Ana Paula [1] ; Bizelli, Vinicius Ferreira [1] ; Francatti, Tamires Mello [1] ; Rezende de Moares Ferreira, Ana Carulina [1] ; Pereira, Jarede Carvalho [1] ; Al-Sharani, Hesham Mohammed [2, 3] ; Lucas, Flavia de Almeida [4] ; Faverani, Leonardo Perez [1]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Diag & Surg, BR-16015050 Sao Paulo - Brazil
[2] Ibb Univ, Sch Dent, Fac Dent, Ibb - Yemen
[3] Harbin Med Univ, Sch Stomatol, Dept Maxillofacial Surg, Harbin 150081 - Peoples R China
[4] UNESP Sao Paulo State Univ, Aracatuba Vet Med Sch, BR-16050680 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: MEMBRANES; v. 11, n. 2 FEB 2021.
Web of Science Citations: 1

Biomaterials for use in guided bone regeneration (GBR) are constantly being investigated and developed to improve clinical outcomes. The present study aimed to comparatively evaluate the biological performance of different membranes during the bone healing process of 8 mm critical defects in rat calvaria in order to assess their influence on the quality of the newly formed bone. Seventy-two adult male rats were divided into three experimental groups (n = 24) based on the membranes used: the CG-membrane-free control group (only blood clot, negative control), BG-porcine collagen membrane group (Bio-Guide(R), positive control), and the PCL-polycaprolactone (enriched with 5% hydroxyapatite) membrane group (experimental group). Histological and histometric analyses were performed at 7, 15, 30, and 60 days postoperatively. The quantitative data were analyzed by two-way ANOVA and Tukey's test (p < 0.05). At 7 and 15 days, the inflammatory responses in the BG and PCL groups were significantly different (p < 0.05). The PCL group, at 15 days, showed a large area of newly formed bone. At 30 and 60 days postoperatively, the PCL and BG groups exhibited similar bone healing, including some specimens showing complete closure of the critical defect (p = 0.799). Thus, the PCL membrane was biocompatible, and has the potential to help with GBR procedures. (AU)

FAPESP's process: 14/24360-9 - Evaluation of the repair process in rats calvarial defects with PCL and porcine collagen membrane: histometric and histological analysis
Grantee:Tamires Melo Francati
Support type: Scholarships in Brazil - Scientific Initiation