| Full text | |
| Author(s): |
dos Santos Sampaio, Maria de Fatima
[1, 2]
;
Giraldi-Guimaraes, Arthur
[2]
;
Lourenco, Camila da Silva
[3]
;
Pereira, Messias Gonzaga
[4]
;
Coimbra, Norberto Cysne
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Fluminense State Univ, UENF, Ctr Biosci & Biotechnol Darcy Ribeiro Northern, Lab Tissue & Cellular Biol, Ave Alberto Lamego 2000, BR-28013602 Campos Dos Goytacazes, RJ - Brazil
[3] Darcy Ribeiro Northern Fluminense State Univ UENF, Lab Clin & Surg, Ave Alberto Lamego 2000, BR-28013602 Campos Dos Goytacazes, RJ - Brazil
[4] Darcy Ribeiro Northern Fluminense State Univ UENF, Lab Plant Breeding, Ave Alberto Lamego 2000, BR-28013602 Campos Dos Goytacazes, RJ - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | BMC RESEARCH NOTES; v. 13, n. 1 JUN 3 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
ObjectivesMany therapies have been proposed in order to investigate the mechanisms of neural repair associated with neurological diseases, including bone marrow mononuclear cells (BMMC) transplantation. However, there is evidence that some encephalic injuries are less responsive to neural repair, such as, for example, cortical ablation. On the other hand, some models of cortical ablation have shown functional recovery after BMMC transplantation. Thus, it is relevant to expand the knowledge of BMMC transplantation-induced neuroplasticity in animal models, considering a promising approach for the rehabilitation of patients with neurological diseases. Using an experimental model of cerebral cortex ablation in adult male Wistar rats, which is known to be poorly responsive to neuroplasticity, the aim of this study was to investigate the effects of BMMC on axonal sprouting in cortico-cortical and cortico-striatal pathways synaptic fields. An anterograde neurotracer was used to evaluate the distribution of axonal fibres.ResultsThe results showed that BMMC were not able to significantly induce axonal sprouting in the evaluated synaptic fields. Our results reinforced the idea that cortical ablation may be less responsive to neuroplasticity and the beneficial effects of BMMC therapy depend on the particularities of a neural microenvironment intrinsic to a given cortical lesion. (AU) | |
| FAPESP's process: | 17/11855-8 - Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |