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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunoexpression and Prognostic Significance of Multidrug Resistance Markers in Feline Mammary Carcinomas

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Author(s):
Manoel, Veronica Correia [1] ; Teles De Carvalho, Pedro Luis [2] ; Govoni, Veronica Mollica [1] ; Da Silva, Tereza Cristina [1] ; Queiroga, Felisbina Luisa [2] ; Cogliati, Bruno [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Pathol, Sch Vet Med & Anim Sci, Sao Paulo - Brazil
[2] Univ Tras Os Montes & Alto Douro, Ctr Res & Technol Agroenvironm & Biol Sci, Vila Real - Portugal
Total Affiliations: 2
Document type: Journal article
Source: Journal of Comparative Pathology; v. 183, p. 13-25, FEB 2021.
Web of Science Citations: 0
Abstract

Feline mammary carcinomas (FMCs) are commonly characterized by high clinical aggressiveness and poor prognosis. FMCs share many features with the corresponding human disease, allowing the comparative investigation of tumour biology and therapeutic strategies, including multidrug resistance (MDR) mechanisms. Although transporting/binding proteins, including permeability glycoprotein (P-gp), lung resistance protein (LRP) and metallothionein (MT), are frequently associated with tumour aggressiveness and unresponsiveness to chemotherapy in human breast cancer, they have not been analysed in FMCs. We investigated the immunoexpression of P-gp, LRP and MT in FMCs and their correlation with clinicopathological parameters and overall survival (OS) time in 46 FMCs, with a median follow-up period of 289 days. These markers were co-expressed in 85% of tumours. P-gp was expressed in 93.4% of FMCs and was positively associated with tumour grade (P = 0.049). While unequivocally observed in all FMCs, LRP immunoexpression did not correlate with any clinicopathological parameters or OS. Expression of MT was significant in triple-negative basal- and normal-like molecular subtypes of FMCs (P = 0.023). The concurrent expression of MDR proteins indicates the potential existence of chemotherapy resistance-related mechanisms in FMCs. The positive association between P-gp and MT immunoexpression and aggressive phenotypes could open new therapeutic and translational strategies for FMCs. (C) 2020 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/15689-0 - Mutational evaluation of BRCA1 and BRCA2 genes in breast tumors in cats and correlation with clinical, histopathological and immunohistochemical aspects
Grantee:Verônica Mollica Govoni
Support Opportunities: Scholarships in Brazil - Master