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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Altered expression of genes related to innate antifungal immunity in the absence of galectin-3

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Author(s):
Rezende, Caroline Patini [1] ; Martins Oliveira Brito, Patricia Kellen [2] ; Pessoni, Andre Moreira [1] ; Da Silva, Thiago Aparecido [2] ; Goldman, Gustavo H. [3] ; Almeida, Fausto [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cellular & Mol Biol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: VIRULENCE; v. 12, n. 1, p. 981-988, JAN 1 2021.
Web of Science Citations: 0
Abstract

Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises beta-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system. (AU)

FAPESP's process: 16/25167-3 - Influence of galectin-3 on course of infection by Cryptococcus neoformans
Grantee:Caroline Patini de Rezende
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/03322-7 - Role of galectin-3 in the Cryptococcus neoformans infection
Grantee:Fausto Bruno dos Reis Almeida
Support type: Research Grants - Young Investigators Grants