| Full text | |
| Author(s): |
Rezende, Caroline Patini
[1]
;
Martins Oliveira Brito, Patricia Kellen
[2]
;
Pessoni, Andre Moreira
[1]
;
Da Silva, Thiago Aparecido
[2]
;
Goldman, Gustavo H.
[3]
;
Almeida, Fausto
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cellular & Mol Biol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | VIRULENCE; v. 12, n. 1, p. 981-988, JAN 1 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises beta-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system. (AU) | |
| FAPESP's process: | 16/03322-7 - Role of galectin-3 in the Cryptococcus neoformans infection |
| Grantee: | Fausto Bruno dos Reis Almeida |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/25167-3 - Influence of galectin-3 on course of infection by Cryptococcus neoformans |
| Grantee: | Caroline Patini de Rezende |
| Support Opportunities: | Scholarships in Brazil - Master |