| Full text | |
| Author(s): |
Machado, Francielly Cristina
[1]
;
Bittar, Cintia
[1]
;
Rahal, Paula
[1]
;
Calmon, Marilia Freitas
[1]
Total Authors: 4
|
| Affiliation: | [1] Sao Paulo State Univ, UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, IBILCE, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, BR-15054010 Sao Jose De Rio Preto, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | ARCHIVES OF VIROLOGY; v. 166, n. 6 APR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Infection with distinct Zika virus (ZIKV) strains in in vitro and in vivo models has demonstrated that the host's response to infection is strain-dependent. There has been no analysis of the impact of infection with different ZIKV strains on miRNA expression in human cells. We investigated miRNA expression in PNT1A cells upon infection with an African ZIKV strain (MR766) and a Brazilian ZIKV strain (ZIKV(BR)) using PCR array. Sixteen miRNAs were modulated in PNT1A cells: six miRNAs were modulated by both strains, while a set of ten miRNAs were modulated exclusively by ZIKV(BR) infection. In silico analysis showed that nine significant KEGG pathways and eight significant GO terms were predicted to be enriched upon ZIKV(BR) infection, and these pathways were related to cancer, environmental information processing, metabolism, and extracellular matrix. Differential modulation of miRNA expression suggests that distinct strains of ZIKV can differentially modulate the host response through the action of miRNAs. (AU) | |
| FAPESP's process: | 17/09197-2 - Analysis of miRNA expression in human prostate cells infected with Zika virus |
| Grantee: | Francielly Cristina Machado |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 14/22198-0 - Therapeutic potential of Flavonoid-like drugs on Hepatitis C virus infection |
| Grantee: | Paula Rahal |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/16660-5 - Analysis of the nanoemulsions associated with photodynamic therapy in the treatment of breast cancer |
| Grantee: | Marilia de Freitas Calmon |
| Support Opportunities: | Regular Research Grants |