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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cholesterol-rich nanoemulsion (LDE) as a novel drug delivery system to diagnose, delineate, and treat human glioblastoma

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Tedesco, Antonio Claudio [1] ; Silva, Emanoel P. O. [1] ; Jayme, Cristiano C. [1] ; Piva, Henrique L. [1] ; Franchi, Leonardo P. [1, 2]
Total Authors: 5
[1] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Photobiol & Photomed Res Grp, Dept Chem, Ctr Nanotechnol & Tissue Engn, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Fed Goias UFG, Dept Bioquim & Biol Mol, Inst Ciencias Biol ICB 2, Campus Samambaia, BR-74690900 Goiania, Go - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 123, APR 2021.
Web of Science Citations: 0

We have prepared and characterized a cholesterol-rich nanoemulsion called LDE, a mimic of classic lipoprotein macromolecules, that can be applied as a new drug delivery system for aluminum phthalocyanine chloride (PcAlCl). The LDE containing PcAlCl system prepared herein had mean size and zeta potential of 127 nm and -29 mV, respectively, and encapsulation rate efficiency was 81%, and stability of 17 months. Compared to classical liposomes, LDE was more efficient, especially in brain diseases like glioblastoma (GBM), as revealed by tests on the U-87 MG cell line. The LDEPc formulation did not display dark cytotoxicity, as expected. The best light dose for LDEPc was 1.0 J?cm? 2: its activity was 55% higher than PcAlCl in a compatible organic medium. In the U-87 MG cells, apoptosis was the preferential pathway activated by PDT. These results strongly support the use of LDE as a new theranostic system. (AU)

FAPESP's process: 12/25216-3 - Photophysical and photobiological studies of drug delivery systems for photosensitizer application in photodynamic therapy
Grantee:Emanoel Pedro de Oliveira Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/10237-1 - Development and characterization of scaffolds based on PCL-PGE and DNA applied to tissue engineering for bone regeneration
Grantee:Cristiano Ceron Jayme
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/50181-1 - Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders
Grantee:Antonio Claudio Tedesco
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/11870-9 - Sensitizing cancer cell lines to photodynamic therapy through inhibition of protein APE1
Grantee:Leonardo Pereira Franchi
Support type: Scholarships in Brazil - Post-Doctorate