Ultrathin films to investigate the interaction of nitrofurantoin with phospholipids

Author(s)

Machado, Andre Campos ^[1] ; Caseli, Luciano ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Chem, Rua Sao Nicolau 210, BR-09913030 Diadema, SP - Brazil

• Document type: Journal article
• Source: Thin Solid Films; v. 725, MAY 1 2021.
• Web of Science Citations: 0

Abstract

The molecular properties of the antibiotic nitrofurantoin at liquid interfaces were correlated with effects observed in cellular membrane models, represented by 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine Langmuir monolayers. Nitrofurantoin adsorbs at the films, keeps their compressibility, and stabilizes them, as characterized by tensiometry. Brewster Angle Microscopy and infrared spectroscopy showed that nitrofurantoin induces the formation of aggregates and affects the lipid hydrophilic and hydrophobic chemical environments. Consequently, nitrofurantoin disturbs the cell membrane models, affecting some of their physicochemical properties, including thermodynamic, rheological, morphological, and structural. These results can help understand at the molecular level interactions between the drug and lipidic biological surfaces. (AU)

• FAPESP's process: 18/25943-9 - Study of the interaction of nitrofurantoin in cellular membrane models through Langmuir films
• Grantee: André Campos Machado
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/03239-0 - Nanostructured interfaces for the investigation of bioactive substances in cell membrane models and for the construction of optoelectronic devices
• Grantee: Luciano Caseli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants