Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Artepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: A review on pharmacological aspects

Full text
Author(s):
Beserra, Fernando Pereira [1, 2] ; Gushiken, Lucas Fernando Sergio [1] ; Hussni, Maria Fernanda [1] ; Ribeiro, Victor Pena [2] ; Bonamin, Flavia [3] ; Jackson, Christopher John [4] ; Pellizzon, Claudia Helena [1] ; Bastos, Jairo Kenupp [2]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Avare Fac EDUVALE, Avare, SP - Brazil
[4] Univ Sydney USYD, Royal North Shore Hosp, Kolling Inst Med Res, Sydney, NSW - Australia
Total Affiliations: 4
Document type: Review article
Source: Phytotherapy Research; v. 35, n. 5, p. 2274-2286, MAY 2021.
Web of Science Citations: 6
Abstract

Propolis is a viscous resin consisting of plant material (shoots, flowers, and plant exudates), salivary secretions and waxes produced byApis melliferabees. Its popular use aroused the interests of scientific research, which proved to be a potential source of various bioactive substances. The chemical composition of propolis depends on several factors, such as the different types of plant sources collected by bees, geographic origin, and the time of year in which they are produced, but it is known that phenolic represent the main bioactive constituents of propolis.Baccharis dracunculifoliaDC (Asteraceae) is the most important botanical source of propolis and a native to southeastern Brazil. It is widely known as the green propolis because of its deep green color. One of its major phenolic acids is artepillin C (Art-C), a diprenyl-p-hydroxycinnamic acid derivative. This review aims to provide a comprehensive summary of the pharmacological effects of Art-C. The limited number of publications on this topic over the past two decades have been collected from databases and summarized. Numerous biological activities have been described for the Art-C, such as gastroprotective, anti-inflammatory, antimicrobial, antioxidant, antitumor. This article describes aspects of occurrence, synthesis, biological activities and pharmacokinetic approaches. (AU)

FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants