Evaluation of bone erosion in rheumatoid arthritis patients by high-resolution peripheral quantitative computed tomography scans: Comparison between two semi-automated programs in a three-dimensional setting

Author(s)

Figueiredo, Camille Pinto ^[1] ; Perez, Mariana Ortega ^[1] ; Sales, Lucas Peixoto ^[1] ; Caparbo, Valeria de Falco ^[1] ; Rodrigues Pereira, Rosa Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Rheumatol Div, Bone Metab Lab, Fac Med FMUSP, Av Dr Arnaldo 455, 3 Andar, Sala 3193, BR-01246903 Sao Paulo - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES; v. 24, n. 7 JUN 2021.
• Web of Science Citations: 0

Abstract

Aim The aim of this study was to compare OsiriX software with the previous published Medical Image Analysis Framework (MIAF) method to assess the volume of erosion in patients with rheumatoid arthritis (RA). Methods Forty RA patients underwent high-resolution peripheral quantitative computed tomography scans of the second and third metacarpophalangeal joints, and thirty-four patients with any bone erosion were enrolled. Two techniques were applied to erosion evaluation: (a) semi-automated MIAF software, and (b) semi-automated segmentation by free open-source Digital Imaging and Communications in Medicine viewer, OsiriX software. MIAF has been published before, but this is the first time that OsiriX has been used in this way in rheumatology. Bland \& Altman plots described agreement between methods. Results Forty-eight erosions from 34 patients were analyzed. Mean age was 40.74 +/- 5.32 years and mean disease duration was 10.68 +/- 4.96 years. Both methods demonstrated a strong correlation regarding erosion volume (r = 0.96, P < 0.001). Median (interquartile range) of erosion volume was 12.14 (4.5-36.07) when MIAF was considered, and 11.80 (3.45-29.42) when the OsiriX tool was used (P = 0.139). MIAF and OsiriX showed good agreement when the Bland \& Altman plot was performed. Evaluation by MIAF took 22.69 +/- 6.71 minutes, whereas OsiriX took only 2.62 +/- 1.09 minutes (P < 0.001). Conclusion The three-dimensional segmentation of bone erosions can be done by both MIAF and OsiriX software with good agreement. However, because OsiriX is a widespread tool and faster, its method seems to be more feasible for evaluating peripheral bone damage, especially bone erosions. (AU)

• FAPESP's process: 16/00006-7 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables
• Grantee: Eduardo Ferreira Borba Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/01315-9 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis patients: association with clinical and genetic variables
• Grantee: Camille Pinto Figueiredo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral