Scandium(III)-Triflate-Catalyzed Multicomponent Reactions for the Synthesis of Nitrogen Heterocycles

Author(s)

Longo, Jr., Luiz S. ^[1] ; Siqueira, Fernanda A. ^[2] ; Anjos, Nicolas S. ^[1] ; Santos, Gabriela F. D. ^[1]

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Dept Pharmaceut Sci, Rua Sao Nicolau 210, BR-09913030 Diadema, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Dept Chem, Rua Prof Arthur Riedel 275, BR-09972270 Diadema, SP - Brazil

• Document type: Review article
• Source: CHEMISTRYSELECT; v. 6, n. 20, p. 5097-5109, MAY 27 2021.
• Web of Science Citations: 1

Abstract

The need of understanding the interactions between small organic molecules and biological targets has stimulated the development of new methodologies for the synthesis of compounds with potential biological properties. In this scenario, multicomponent reactions have been considered as high atom-efficient strategies which allow the generation of high levels of molecular diversity and complexity, using relatively simple and eco-friendly experimental procedures. Among the plethora of catalysts used in multicomponent reactions, rare earth metal triflates, especially scandium(III) triflate {[}Sc(OTf)(3)], emerged as water-resistant Lewis acids with remarkable catalytic activity in water-containing environments. This review describes the recent progress on the use of scandium(III) triflate as Lewis acid catalyst for multicomponent reactions applied to the synthesis of nitrogen-containing heterocycles, valuable privileged scaffolds in Organic and Medicinal Chemistry. (AU)

• FAPESP's process: 18/15038-7 - Tumor development under the perspective of redox signaling: temporal modulation of the production of nitric oxide and reactive oxygen species
• Grantee: Hugo Pequeno Monteiro
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/01314-5 - Lewis acid immobilization onto polymer-supported ionic liquid phases: a x-ray photoelectron spectroscopy study
• Grantee: Luiz Sidney Longo Junior
• Support Opportunities: Scholarships abroad - Research