| Grant number: | 17/19940-4 |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): | November 01, 2017 |
| Effective date (End): | July 31, 2020 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Cooperation agreement: | GlaxoSmithKline |
| Principal Investigator: | Arlene Gonçalves Corrêa |
| Grantee: | Natália Menezes Moreira |
| Home Institution: | Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil |
| Associated research grant: | 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE |
Abstract Neglected diseases caused by protozoan Leishmania and Trypanosoma affect thousands of people every year, in most cases leading to death of many infected. Most of drugs used on treatment of these diseases are not efficient in chronic stages of them and normally exhibit high toxicity. Therefore, the study to obtain new compounds that exhibit antiparasital activity is very important. In this context, quinazolines are important heterocycles because of the wide variety of biological applications, found in various drugs currently commercialized. This project aims the synthesis and evaluation of antiparasital activity of a series of quinazolines, employing concepts of Green Chemistry, including C-H functionalization reactions and multicomponent reactions. (AU) | |