Synthesis and evaluation of antiparasitic activity of quinazolines employing multicomponent reactions and C-H functionalization

• Grant number: 17/19940-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: November 01, 2017
• End date: January 12, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Agreement: GlaxoSmithKline
• Principal Investigator: Arlene Gonçalves Corrêa
• Grantee: Natália Menezes Moreira Borges
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE
• Associated scholarship(s): 19/10608-2 - Visible-light photoredox C-H functionalization of heteroarenes with aminonitriles, BE.EP.DD

Abstract

Neglected diseases caused by protozoan Leishmania and Trypanosoma affect thousands of people every year, in most cases leading to death of many infected. Most of drugs used on treatment of these diseases are not efficient in chronic stages of them and normally exhibit high toxicity. Therefore, the study to obtain new compounds that exhibit antiparasital activity is very important. In this context, quinazolines are important heterocycles because of the wide variety of biological applications, found in various drugs currently commercialized. This project aims the synthesis and evaluation of antiparasital activity of a series of quinazolines, employing concepts of Green Chemistry, including C-H functionalization reactions and multicomponent reactions. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, NATALIA M.; DOS SANTOS, JHONATHAN R. N.; CORREA, ARLENE G.. Greener Synthesis of Pyrroloquinazoline Derivatives: Recent Advances. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. N/A, p. 30-pg., 2022-06-13. (17/19940-4, 13/07600-3, 20/10349-4, 14/50249-8)

MOREIRA, NATALIA M.; MARTELLI, LORENA S. R.; CORREA, ARLENE G.. Asymmetric organocatalyzed synthesis of coumarin derivatives. Beilstein Journal of Organic Chemistry, v. 17, p. 1952-1980, AUG 3 2021. (20/10349-4, 14/50249-8, 17/19940-4, 13/07600-3, 18/23761-0)

LIMA, CAROLINA G. S.; MOREIRA, NATALIA M.; PAIXAO, MARCIO W.; CORREA, ARLENE G.. Heterogenous green catalysis: Application of zeolites on multicomponent reactions. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, v. 15, n. SI, p. 7-12, FEB 2019. (15/17141-1, 14/50249-8, 17/19940-4, 13/07600-3)

LIMA, CAROLINA G. S.; MOREIRA, NATALIA M.; PAIXAO, MARCIO W.; CORREA, ARLENE G.. Heterogenous green catalysis: Application of zeolites on multicomponent reactions. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, v. 15, p. 6-pg., 2019-02-01. (17/19940-4, 14/50249-8, 13/07600-3, 15/17141-1)

MOREIRA, NATAILIA M.; DE MIRANDA, INGRID T.; DOS SANTOS, JHONATHAN R. N.; OPATZ, TILL; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; CORREA, ARLENE G.. Copper-Catalyzed Synthesis of Pyrrolo[1,2-c]quinazolines and Pyrrolo[2,1-a]isoquinolines and Antiplasmodial Evaluation. Journal of Organic Chemistry, v. 88, n. 13, p. 10-pg., 2023-06-05. (16/20609-8, 13/07600-3, 14/50249-8, 17/19940-4, 20/12904-5, 20/10349-4, 22/01066-4)