| Full text | |
| Author(s): Show less - |
de Souza, Debora Maria Soares
[1, 2, 3]
;
Silva, Maria Claudia
[4]
;
Farias, Silvia Elvira Barros
[1]
;
Menezes, Ana Paula de J.
[1]
;
Milanezi, Cristiane Maria
[4]
;
Lucio, Karine de P.
[5]
;
Paiva, Nivia Carolina N.
[6]
;
de Abreu, Paula Melo
[2]
;
Costa, Daniela Caldeira
[3, 5]
;
Pinto, Kelerson Mauro de Castro
[1, 7]
;
Costa, Guilherme de Paula
[1, 3]
;
Silva, Joao Santana
[4, 8]
;
Talvani, Andre
[1, 3, 9]
Total Authors: 13
|
| Affiliation: | [1] Univ Fed Ouro Preto, Dept Biol Sci, Lab Immunobiol Inflammat, Ouro Preto - Brazil
[2] Univ Fed Ouro Preto, Biol Sci Postgrad Program, Ouro Preto - Brazil
[3] Univ Fed Ouro Preto, Hlth & Nutr Postgrad Program, Ouro Preto - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Sao Paulo - Brazil
[5] Univ Fed Ouro Preto, Dept Biol Sci, Lab Metab Biochem, Ouro Preto - Brazil
[6] Univ Fed Ouro Preto, Ctr Res Biol Sci, Ouro Preto - Brazil
[7] Univ Fed Ouro Preto, Sch Phys Educ, Ouro Preto - Brazil
[8] Univ Sao Paulo, Ribeirao Preto Med Sch, Fiocruz Bi Inst Translat Med Plataform, Sao Paulo - Brazil
[9] Univ Fed Minas Gerais, Infectol & Trop Med Postgrad Program, Hlth Sci, Belo Horizonte, MG - Brazil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | FRONTIERS IN CARDIOVASCULAR MEDICINE; v. 8, MAY 25 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Trypanosoma cruzi is a protozoan parasite that causes Chagas disease and affects 6-7 million people mainly in Latin America and worldwide. Here, we investigated the effects of hyperlipidic diets, mainly composed of olive oil or lard on experimental T. cruzi infection. C57BL/6 mice were fed two different dietary types in which the main sources of fatty acids were either monounsaturated (olive oil diet) or saturated (lard diet). Methods: After 60 days on the diet, mice were infected with 50 trypomastigote forms of T. cruzi Colombian strain. We evaluated the systemic and tissue parasitism, tissue inflammation, and the redox status of mice after 30 days of infection. Results: Lipid levels in the liver of mice fed with the lard diet increased compared with that of the mice fed with olive oil or normolipidic diets. The lard diet group presented with an increased parasitic load in the heart and adipose tissues following infection as well as an increased expression of Tlr2 and Tlr9 in the heart. However, no changes were seen in the survival rates across the dietary groups. Infected mice receiving all diets presented comparable levels of recruited inflammatory cells at 30 days post-infection but, at this time, we observed lard diet inducing an overproduction of CCL2 in the cardiac tissue and its inhibition in the adipose tissue. T. cruzi infection altered liver antioxidant levels in mice, with the lard diet group demonstrating decreased catalase (CAT) activity compared with that of other dietary groups. Conclusions: Our data demonstrated that T. cruzi growth is more favorable on tissue of mice subjected to the lard diet. Our findings supported our hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology. (AU) | |
| FAPESP's process: | 13/08216-2 - CRID - Center for Research in Inflammatory Diseases |
| Grantee: | Fernando de Queiroz Cunha |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |