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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19

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Alberca, Ricardo Wesley [1] ; Rigato, Paula Ordonhez [2] ; Leuzzi Ramos, Yasmim Alefe [1] ; Emidio Teixeira, Franciane Mouradian [3, 1] ; Calvielli Branco, Anna Claudia [3, 1] ; Fernandes, Iara Grigoletto [1] ; Pietrobon, Anna Julia [3, 1] ; da Silva Duarte, Alberto Jose [1] ; Aoki, Valeria [1] ; Orfali, Raquel Leao [1] ; Sato, Maria Notomi [1]
Total Authors: 11
[1] Univ Sao Paulo, Fac Med FMUSP, Inst Med Trop, Dept Dermatol, Lab Dermatol & Imunodeficiencias LI, Sao Paulo - Brazil
[2] Adolfo Lutz Inst, Immunol Ctr, Tech Div Med Biol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN NUTRITION; v. 8, JUN 2 2021.
Web of Science Citations: 0

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease-2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic challenges worldwide. Several risk factors, such as age, co-infections, metabolic syndrome, and smoking have been associated with poor disease progression and outcomes. Alcohol drinking is a common social practice among adults, but frequent and/or excessive consumption can mitigate the anti-viral and anti-bacterial immune responses. Therefore, we investigated if patients with self-reported daily alcohol consumption (DAC) presented alteration in the immune response to SARS-CoV-2. We investigated 122 patients with COVID-19 (101 male and 46 females), in which 23 were patients with DAC (18 men and 5 women) and 99 were non-DAC patients (58 men and 41 women), without other infections, neoplasia, or immunodeficiencies. Although with no difference in age, patients with DAC presented an increase in severity-associated COVID-19 markers such as C-reactive protein (CRP), neutrophil count, and neutrophil-to-lymphocyte ratio. In addition, patients with DAC presented a reduction in the lymphocytes and monocytes counts. Importantly, the DAC group presented an increase in death rate in comparison with the non-DAC group. Our results demonstrated that, in our cohort, DAC enhanced COVID-19-associated inflammation, and increased the number of deaths due to COVID-19. (AU)

FAPESP's process: 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring
Grantee:Maria Notomi Sato
Support type: Regular Research Grants