| Full text | |
| Author(s): |
de Assis, Leonardo Vinicius Monteiro
[1, 2]
;
Tonolli, Paulo Newton
[3]
;
Moraes, Maria Nathalia
[4]
;
Baptista, Mauricio S.
[5]
;
Castrucci, Ana Maria de Lauro
[1, 6]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biosci, Dept Physiol, Sao Paulo - Brazil
[2] Univ Lubeck, Ctr Brain Behav & Metab, Inst Neurobiol, Lubeck - Germany
[3] Univ Sao Paulo, Inst Biosci, Human Genome & Stem Cell Res Ctr, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[6] Univ Virginia, Dept Biol, Charlottesville, VA 22903 - USA
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS; v. 47, JUN 2021. |
| Web of Science Citations: | 10 |
| Abstract | |
The consensus on the effects of excessive sun exposure on human health has long emphasized the negative effects of solar UV radiation. Nevertheless, although UV radiation has been demonized, less is known about the consequences of sun exposure while using sunscreen, which can lead to high visible light exposure. UV and visible light play key roles in vitamin D synthesis, reduction of blood pressure, among other beneficial effects. In this review, we aim to provide a comprehensive view of the wide range of responses of the human skin to sunlight by revisiting data on the beneficial and harmful effects of UV and visible light. We start by exploring the interaction of photons in the skin at several levels including physical (depth of photon penetration), chemical (light absorption and subsequent photochemical events), and biological (how cells and tissues respond). Skin responses to sun exposure can only be comprehensively understood through a consideration of the light-absorbing molecules present in the skin, especially the light-sensing proteins called opsins. Indeed, many of the cellular responses to sun exposure are modulated by opsins, which act as the \& ldquo;eyes of the skin \& rdquo;. (c) 2021 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 17/24615-5 - Breaking a paradigm? Melanopsin, a canonical photo-pigment, acting as sensor to entrain the clock in light unexposed organs, and its putative interaction with TRP channels: a trans-disciplinary study involving physiological and pathological aspects |
| Grantee: | Ana Maria de Lauro Castrucci |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/14728-0 - Melanopsin as the UVA photoreceptor and its relationship with pigmentation, DNA repair, biological clock and components of the HPA axis: a novel pharmacological target? |
| Grantee: | Ana Maria de Lauro Castrucci |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |