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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Poly(epsilon-caprolactone) grafted cashew gum nanoparticles as an epirubicin delivery system

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Author(s):
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Ribeiro, Irisvan S. [1] ; Pontes, Francisco J. G. [1] ; Carneiro, Maria J. M. [1] ; Sousa, Nayara A. [2] ; Pinto, Vicente P. T. [2] ; Ribeiro, Fabio O. S. [3] ; Silva, Durcilene A. [3] ; Araujo, Gisele S. [4] ; Marinho Filho, Jose D. B. [4] ; Araujo, Ana J. [3] ; Paula, Haroldo C. B. [1] ; Feitosa, Judith P. A. [1] ; de Paula, Regina C. M. [1]
Total Authors: 13
Affiliation:
[1] Univ Fed Ceara, Dept Organ & Inorgan Chem, Fortaleza, Ceara - Brazil
[2] Univ Fed Ceara, Fac Med, Sobral, Ceara - Brazil
[3] Fed Univ Delta Parnaiba, UFDPar, BIOTEC, Res Ctr Biodivers & Biotechnol, Parnaiba, PI - Brazil
[4] Fed Univ Delta Parnaiba, UFDPar, LCC Delta, Cell Culture Lab Delta, Parnaiba, PI - Brazil
Total Affiliations: 4
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 179, p. 314-323, MAY 15 2021.
Web of Science Citations: 0
Abstract

Polysaccharide based copolymers have been the focus of several research, particularly for the development of drug delivery systems. This study reports on the preparation of nanoparticles from an amphiphilic copolymer obtained by the poly(epsilon-caprolactone) graft in the structure of cashew gum, via ring-opening polymerization. The synthesis of copolymers was confirmed by Fourier transform infrared spectroscopy and nuclear magnetic resonance. The copolymers exhibit self-organization capability in water, with critical association concentration of 42 and 50 mu g mL(-1). The nanoparticle hydrodynamic diameters (212 and 202 nm) revealed a decreasing trend with increasing poly(epsilon-caprolactone) graft percentage. Epirubicin was used as an anticancer drug model and incorporated into the nanoparticles. The encapsulation efficiency reached 50% and 5.0% drug load. Nanoparticles showed an epirubicin controlled release profile, with maximum release of 93.0 +/- 4.0% in 72 h, as well as excellent biocompatibility, according to hemolysis and cytotoxicity assays. (C) 2021 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants