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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Role of GPNMB in Inflammation

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Author(s):
Saade, Marina [1] ; de Souza, Giovanna Araujo [1] ; Scavone, Cristoforo [1] ; Kinoshita, Paula Fernanda [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 12, MAY 12 2021.
Web of Science Citations: 0
Abstract

Inflammation is a response to a lesion in the tissue or infection. This process occurs in a specific manner in the central nervous system and is called neuroinflammation, which is involved in neurodegenerative diseases. GPNMB, an endogenous glycoprotein, has been recently related to inflammation and neuroinflammation. GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively. Some studies have shown increased levels of GPNMB in pro-inflammatory conditions, such as LPS treatment, and in pathological conditions, such as neurodegenerative diseases and cancer. However, the role of GPNMB in inflammation is still not clear. Even though most studies suggest that GPNMB might have an anti-inflammatory role by promoting inflammation resolution, there is evidence that GPNMB could be pro-inflammatory. In this review, we gather and discuss the published evidence regarding this interaction. (AU)

FAPESP's process: 18/14289-6 - The role of Klotho protein in Alzheimer's disease
Grantee:Paula Fernanda Kinoshita
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/07427-8 - Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system
Grantee:Cristoforo Scavone
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/05970-4 - Effects of ±-Klotho protein in TNF-± signaling through TNFR1 in glia primary culture
Grantee:Giovanna Araujo de Souza
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/07896-3 - Effects of GPNMB pretein in the modulation of inflammatory processes induced by LPS in microglial cells and astrocytes rat cells
Grantee:Marina Saade
Support Opportunities: Scholarships in Brazil - Master