Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report

Author(s):Show less -

Pecanha, Paulo Mendes ^[1] ; Bahiense, Isabela Cruz ^[1] ; Lima Kruschewsky, Wdson Luis ^[1] ; Biasutti, Claudia ^[2] ; Goncalves Ferreira Junior, Carlos Urbano ^[2] ; Pinheiro, Breno Goncalves ^[3] ; Maifrede, Simone Bravim ^[1] ; de Camargo, Zoilo Pires ^[3] ; Rodrigues, Anderson Messias ^[3] ; Grao-Velloso, Tania Regina ^[1] ; Falqueto, Aloisio ^[1] ; Goncalves, Sarah Santos ^[1]

Affiliation

^[1] Univ Fed Espirito Santo UFES, Vitoria, ES - Brazil

^[2] Hosp Univ Cassiano Antonio Moraes UFES, Vitoria, ES - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Sao Paulo - Brazil

• Document type: Journal article
• Source: REVISTA IBEROAMERICANA DE MICOLOGIA; v. 38, n. 1, p. 5-8, JAN-MAR 2021.
• Web of Science Citations: 1

Abstract

Background: Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetenthosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms. Case report: We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as Paracoccidioides brasiliensis S1 by species-specific PCR using primers for protein-coding gene GP43 (exon 2) followed by PCR-RFLP of the alpha-tubulin gene. Conclusions: There are few data in literature reporting species-specific molecular identification of Paracoccidioides in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients. (C) 2020 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved. (AU)

• FAPESP's process: 17/27265-5 - Molecular epidemiology and genomic perspectives on the evolution and spread of emerging fungal pathogens
• Grantee: Anderson Messias Rodrigues
• Support Opportunities: Research Grants - Young Investigators Grants