Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration

Author(s)

Zanatelli, Marianna ^[1] ; Colleta, Simone Jacovaci ^[2] ; Guerra, Luiz Henrique Alves ^[2] ; Santos, Fernanda Cristina Alcantara ^[3] ; Goes, Rejane Maira ^{[1, 2]} ; Vilamaior, Patricia Simone Leite ^[2] ; Taboga, Sebastiao Roberto ^{[1, 2]}

Affiliation

^[1] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil

^[2] Sao Paulo State Univ UNESP IBILCE, Dept Biol, Lab Microscopy & Microanal, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Fed Univ Goias UFG, Dept Morphol, Goiania, Go - Brazil

• Document type: Journal article
• Source: Reproductive Biology and Endocrinology; v. 19, n. 1 JUN 22 2021.
• Web of Science Citations: 0

Abstract

Background The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, having already been identified in the tissue, acting through its receptor PRLR. In the Mongolian gerbil, in addition to the male prostate, the female prostate is also well developed and active in its secretion processes. The aim of the present study was to evaluate the effects of exposure to exogenous prolactin in the prostate of both intact and castrated male and female gerbils in order to establish if prolactin administration can sustain prostate cell activity in conditions of sexual hormone deprivation. Methods The morphological analyses were performed by biometric analysis, lesion histological analysis and morphometric-stereological aspects. In addition, immune-cytochemical tests were performed for prolactin and its receptor, as well as for the receptors of androgen and oestrogen and serum prolactin dosage. All data were submitted to ANOVA or Kruskal-Wallis tests for comparison between groups. P < 0.05 was considered to be statistically significant. Results The results showed a strong influence of prolactin on the morphology of the prostate, with the development of important epithelial alterations, after only 3 days of administration, and an expressive epithelial cell discard process after 30 days of administration. Prolactin acts in synergy with testosterone in males and mainly with oestrogens in females, establishing different steroid hormonal receptor immunoreactivity according to sex. It was also demonstrated that prolactin can assist in the recovery from some atrophic effects caused in the gland after castration, without causing additional tissue damage. Conclusions The prolactin and its receptor are involved in the maintenance of the homeostasis of male and female gerbils, and also cause distinct histological alterations after exogenous exposure for 3 and 30 days. The effects of prolactin are related to its joint action on androgens and oestrogens and it can also assist in the recovery from the atrophic effects of castration. (AU)

• FAPESP's process: 12/00695-6 - Repercussion of prolactin and its inhibitor, bromocriptine, in epithelial-stromal interactions of Mongolian gerbil prostate
• Grantee: Marianna Zanatelli
• Support Opportunities: Scholarships in Brazil - Doctorate