The protective roles of clusterin in ocular diseases caused by obesity and diabetes mellitus type 2

Author(s):Show less -

de Campos, Thais Dantis Pereira ^[1] ; da Cruz Rodrigues, Kellen Cristina ^[1] ; Pereira, Rodrigo Martins ^[1] ; Anaruma, Chadi Pellegrini ^[1] ; dos Santos Canciglieri, Raphael ^[1] ; de Melo, Diego Gomes ^[1] ; da Silva, Adelino Sanchez Ramos ^[2] ; Cintra, Dennys Esper ^{[3, 4]} ; Ropelle, Eduardo Rochete ^{[3, 1]} ; Pauli, Jose Rodrigo ^{[3, 1]} ; de Moura, Leandro Pereira ^{[3, 1, 5]}

Affiliation

^[1] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, 1300 Pedro Zaccaria St, Limeira, SP - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[3] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Limeira, SP - Brazil

^[4] Univ Estadual Campinas, Sch Appl Sci, Lab Nutrit Genom LABGeN, Limeira, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Postgrad Program Motr Sci, Sao Paulo - Brazil

• Document type: Review article
• Source: MOLECULAR BIOLOGY REPORTS; v. 48, n. 5, p. 4637-4645, MAY 2021.
• Web of Science Citations: 0

Abstract

Obesity is a chronic, non-transmissible and multifactorial disease commonly associated with systemic inflammation and damage to health. This disorder has been pointed out as leading to the development of a diversity of eye diseases and, consequently, damage to visual acuity. More specifically, cardiometabolic risk is associated with lacrimal gland dysfunctions, since it changes the inflammatory profile favoring the development and worsening of dry eye disease. In more severe and extreme cases, obesity, inflammation, and diabetes mellitus type 2 can trigger the total loss of vision. In this scenario, besides its numerous metabolic functions, clusterin, an apolipoprotein, has been described as protective to the ocular surface through the seal mechanism. Thus, the current review aimed to explain the role of clusterin in dry eye disease that can be triggered by obesity and diabetes. (AU)

• FAPESP's process: 18/06833-8 - Could physical exercise improve visual acuity? Effects of different physical training protocols on tear composition and clusterin/ApoJ metabolism in the retina of obese rodent
• Grantee: Thaís Dantis Pereira de Campos
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 15/07199-2 - Role of clusterin/ApoJ on insulin signalling in response to physical exercise in rodents and humans
• Grantee: Leandro Pereira de Moura
• Support type: Research Grants - Young Investigators Grants