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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

nterplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cance

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Aguayo, Francisco [1] ; Boccardo, Enrique [2] ; Corvalan, Alejandro [3] ; Calaf, Gloria M. [4, 5] ; Blanco, Rances [6]
Total Authors: 5
[1] Univ Tarapaca, Arica 1000000 - Chile
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Lab Oncovirol, Sao Paulo - Brazil
[3] Pontificia Univ Catolic Chile, Adv Ctr Chron Dis ACCDiS, Santiago - Chile
[4] Univ Tarapaca, Inst Alta Invest, Arica 1000000 - Chile
[5] Columbia Univ, Med Ctr, Ctr Radiol Res, New York, NY 10032 - USA
[6] Univ Chile, Inst Ciencias Biomed ICBM, Fac Med, Programa Virol, Lab Oncovirol, Santiago - Chile
Total Affiliations: 6
Document type: Review article
Source: INFECTIOUS AGENTS AND CANCER; v. 16, n. 1 JUN 30 2021.
Web of Science Citations: 1

Epstein-Barr virus (EBV) is a herpesvirus associated with lymphoid and epithelial malignancies. Both B cells and epithelial cells are susceptible and permissive to EBV infection. However, considering that 90% of the human population is persistently EBV-infected, with a minority of them developing cancer, additional factors are necessary for tumor development. Xenobiotics such as tobacco smoke (TS) components, pollutants, pesticides, and food chemicals have been suggested as cofactors involved in EBV-associated cancers. In this review, the suggested mechanisms by which xenobiotics cooperate with EBV for carcinogenesis are discussed. Additionally, a model is proposed in which xenobiotics, which promote oxidative stress (OS) and DNA damage, regulate EBV replication, promoting either the maintenance of viral genomes or lytic activation, ultimately leading to cancer. Interactions between EBV and xenobiotics represent an opportunity to identify mechanisms by which this virus is involved in carcinogenesis and may, in turn, suggest both prevention and control strategies for EBV-associated cancers. (AU)

FAPESP's process: 19/26065-8 - Regulation of the expression and activity of the matrix metalloproteinase inhibitor RECK by human papillomavirus early proteins: impact on the process of tumor development
Grantee:Enrique Mario Boccardo Pierulivo
Support Opportunities: Regular Research Grants