Comparative study between photodynamic therapy with urucum plus Led and probiotics in halitosis reduction-protocol for a controlled clinical trial

Author(s):Show less -

Motta, Pamella de Barros ^[1] ; Motta, Lara Jansiski ^[1] ; Costa da Mota, Ana Carolina ^[1] ; Leal Goncalves, Marcela Leticia ^{[1, 2]} ; Silva, Tamiris ^[1] ; Momolli, Marcos ^[1] ; de Andrade, David Casimiro ^[3] ; Santos Fernandes, Kristianne Porta ^[1] ; Mesquita-Ferrari, Raquel Agnelli ^[1] ; Deana, Alessandro Melo ^[1] ; Wainwright, Mark ^[4] ; Prates, Renato Araujo ^[1] ; Ratto Tempestini Horliana, Anna Carolina ^[1] ; Bussadori, Sandra Kalil ^{[1, 2]}

Affiliation

^[1] Univ Nove Julho, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, SP - Brazil

^[2] Univ Metropolitana Santos UNIMES, Dent Coll, Santos, SP - Brazil

^[3] Univ Porto, Sch Dent, Porto - Portugal

^[4] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool, Merseyside - England

• Document type: Journal article
• Source: PLoS One; v. 16, n. 5 MAY 14 2021.
• Web of Science Citations: 0

Abstract

Background Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. The aim of the proposed protocol is to determine whether treatment with antimicrobial photodynamic therapy (aPDT) and treatment with probiotics are effective at eliminating halitosis. Materials and methods Eighty-eight patients, from 18 to 25 years old with a diagnosis of halitosis (H2S >= 112 ppb, determined by gas chromatography) will be randomly allocated to four groups (n = 22) that will receive different treatments: Group 1 -treatment with teeth brushing, dental floss and tongue scraper; Group 2 -brushing, dental floss and aPDT; Group 3 -brushing, dental floss and probiotics; Group 4 -brushing, flossing, aPDT and probiotics. The results of the halimetry will be compared before, immediately after, seven days and thirty days after treatment. The microbiological analysis of the coated tongue will be performed at these same times. The normality of the data will be determined using the Shapiro-Wilk test. Data with normal distribution will be analyzed using analysis of variance (ANOVA). Non-parametric data will be analyzed using the Kruskal-Wallis test. The Wilcoxon test will be used to analyze the results of each treatment at the different evaluation periods. Clinical trail registration NCT03996044. (AU)

• FAPESP's process: 19/14229-6 - Comparative study between photodynamic therapy with urucum and LED and probiotics in halitosis reduction: controlled clinical trial
• Grantee: Sandra Kalil Bussadori
• Support Opportunities: Regular Research Grants