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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control

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Author(s):
Lima, Luciana [1] ; Vasconcelos-dos-Santos, Thiago [1] ; Campos, Marliane [1] ; Ramos, Patricia Karla [1] ; Gomes, Claudia [2] ; Laurenti, Marcia [2] ; da Matta, Vania [2] ; Corbett, Carlos [2] ; Silveira, Fernando [1, 3]
Total Authors: 9
Affiliation:
[1] Evandro Chagas Inst, Parasitol Dept, Rod BR 316, KM 07, BR-67030000 Ananindeua, Para - Brazil
[2] Univ Sao Paulo, Med Sch, Pathol Dept, Sao Paulo, SP - Brazil
[3] Fed Univ Para, Nucleus Trop Med, Belem, Para - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PARASITE EPIDEMIOLOGY AND CONTROL; v. 10, AUG 2020.
Web of Science Citations: 1
Abstract

The clinical-immunological spectrum of human Leishmania (L) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous L (L) infantum chagasi-antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human L. (L.) infantum chagasi-infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (Al) {[}DTH+/++++, IFAT(-)], 2) Subclinical Resistant Infection (SRI) {[}DTH+/++++, IFAT(+/++)], and 3) Indeterminate Initial Infection (III) {[}DTH-, IFAT(+/++)], and two symptomatic ones, 4) Symptomatic Infection (SI) {[}-American visceral leishmaniasis - AVLJ and, 5) Subclinical Oligosymplomatic Infection (SOI), both with the same immune profile {[}DTH-, IFAT(+++/++++)]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgMantibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human L. (L.) infantum chagasi-infection in endemic areas as well as optimizing AVL control. (C) 2020 Published by Elsevier Ltd on behalf of World Federation of Parasitologists. (AU)

FAPESP's process: 14/50315-0 - Leishmaniasis in Latin America: an advanced perspective on immunopathogenetic factors of cutaneous and visceral infection, immunomodulators of the sandflies vector saliva and immunogenic exo-antigens of Leishmania (L.) infantum chagasi as vaccine candidates
Grantee:Marcia Dalastra Laurenti
Support Opportunities: Research Projects - Thematic Grants