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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjogren's syndrome: a comparative study

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Author(s):
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Silva, Evanio Vilela [1] ; Almeida, Luciana Yamamoto [1] ; Bortoletto, Karen Cristine [2] ; Quero, Isabela Barbosa [2] ; Jacomini, Fernanda Carolina [2] ; Benevenuto de Andrade, Bruno Augusto [3] ; Silveira, Heitor Albergoni [1] ; Duarte, Andressa [4] ; Petean, Flavio Calil [5] ; Rocha, Eduardo Melani [5] ; Ribeiro-Silva, Alfredo [4] ; Carlos, Roman [6] ; Leon, Jorge Esquiche [2]
Total Authors: 13
Affiliation:
[1] Sao Paulo State Univ, UNESP, Araraquara Dent Sch, Oral Med, Dept Diag & Surg, Araraquara, SP - Brazil
[2] Univ Sao Paulo FORP USP, Sch Dent Ribeirao Preto, Oral Pathol, Dept Stomatol Publ Oral Hlth & Forens Dent, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Fed Univ Rio de Janeiro UFRJ, Sch Dent, Dept Oral Diag & Pathol, Oral Pathol, Rio De Janeiro, RJ - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP USP, Dept Pathol & Forens Med, Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
[6] Hosp Herrera Llerandi AMEDESGUA, Dept Pathol, Guatemala City - Guatemala
Total Affiliations: 6
Document type: Journal article
Source: RHEUMATOLOGY INTERNATIONAL; JUL 2021.
Web of Science Citations: 0
Abstract

Focal lymphocytic sialadenitis (FLS), an important diagnostic criterion for Sjogren's syndrome (SS) diagnosis, can also be observed when assessing minor salivary gland (mSG) biopsies from healthy asymptomatic individuals (non-SS patients). Fifty cases of primary SS (pSS group) and 31 cases of oral reactive lesions (non-SS non-sicca group) containing also typical FLS features, were assessed by morphological and immunohistochemical (CD10, CD23 and Bcl-6) analysis, aiming at the detection of GCs. All pSS cases showed FLS with focus score (FS) >= 1. In the non-SS non-sicca group, 12, 10 and 9 cases showed FLS with FS >= 1, FLS with FS < 1 and FLS associated with chronic sclerosing sialadenitis with FS < 1, respectively. The morphological analysis revealed similar frequency of GCs in pSS (20%) and non-SS non-sicca group (19%). The area (p = 0.052) and largest diameter (p = 0.245) of GCs were higher in pSS than non-SS non-sicca group. The FS and number of foci were significantly higher in pSS than non-SS non-sicca group with FS < 1. Immunohistochemistry confirmed all morphological findings (GCs showing CD23 and Bcl-6 positivity, with variable CD10 expression) and additionally in 3 and 1 cases of the pSS and non-SS non-sicca group, respectively. Moreover, another 6 and 2 cases of the pSS and non-SS non-sicca group with FS >= 1, respectively, showed positivity only for CD23. FLS can also be observed when assessing oral reactive lesions, which showed similar frequency of GCs with those found in pSS patients. Further studies, including functional analysis of lymphocytic populations and GCs in FLS, are encouraged. (AU)

FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies.
Grantee:Luciana Yamamoto de Almeida
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/14636-2 - Clinicopathological correlation between focus score and frequency of germinal centres in the lymphocytic infiltrates in Sjogren's Syndrome
Grantee:Karen Cristine Bortoletto
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
Grantee:Heitor Albergoni da Silveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
Grantee:Jorge Esquiche León
Support Opportunities: Regular Research Grants