| Full text | |
| Author(s): |
Alves, Ana Paula V. D.
[1]
;
Freitas, Amanda B.
[1]
;
Levi, Jose Eduardo
[2]
;
Amorim Filho, Antonio G.
[3]
;
Franco, Lucas A. M.
[4]
;
Hoshida, Mara Sandra
[5]
;
Patino, Elizabeth G.
[1]
;
Francisco, V, Rossana P.
;
Carvalho, Mario Henrique B.
[6]
Total Authors: 9
|
| Affiliation: | [1] V, Univ Sao Paulo, Fac Med FMUSP, Dept Obstet & Ginecol, Disciplina Obstet, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Med Trop, Lab Virol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Clin Obstetr, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Med Trop, Dept Infect Dis, Lab Parasitol, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, LIM57 Lab Fisiol Obstetr, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Fac Med FMUSP, Dept Obstet & Ginecol, Disciplina Obstet, Inst Cent, 10th Floor, Suite 10094 Av Dr Eneas de Carvalho, BR-05403000 Sao Paulo, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | JOURNAL OF PERINATAL MEDICINE; v. 49, n. 5, p. 553-558, 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Objectives: To investigate the association between selected single nucleotide polymorphisms (SNPs) with cervical insufficiency and its relationship with obstetric history. Methods: Twenty-eight women with cervical insufficiency (case group) and 29 non-pregnant women (control group) were included. The SNPs sequenced included rs2586490 in collagen type I alpha 1 chain (COL1A1), rs1882435 in collagen type IV alpha 3 chain (COL4A3), rs2277698 in metallopeptidase inhibitor 2 (TIMP2), and rs1800468 in transforming growth factor beta 1 (TGFB1). Results: We found a higher frequency of the normal allele in the control group (65.5%) and the homozygous mutated genotype in the case group (64.3%) for rs2586490 in COL1A1 (p=0.023). An unplanned finding in the cervical insufficiency group was a higher gestational age of delivery (median >= 38 weeks) in the mutated allele than in the wildtype genotype (median of 28.2 weeks) for rs2857396, which is also in the COL1A1 gene (p=0.011). Conclusions: The findings of the present study corroborate the hypothesis that cervical insufficiency has a genetic component and probably involves genes encoding proteins in the extracellular matrix, in addition to inflammatory processes. (AU) | |
| FAPESP's process: | 12/24920-9 - Association of genetic factor and risk for preterm delivery in women with cervical insufficiency |
| Grantee: | Mario Henrique Burlacchini de Carvalho |
| Support Opportunities: | Regular Research Grants |