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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Broadband measurement of true transverse relaxation rates in systems with coupled protons: application to the study of conformational exchange

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Author(s):
Kiraly, Peter [1, 2] ; Dal Poggetto, Guilherme [3, 1] ; Castanar, Laura [1] ; Nilsson, Mathias [1] ; Deak, Andrea [4] ; Morris, Gareth A. [1]
Total Authors: 6
Affiliation:
[1] Univ Manchester, Dept Chem, Oxford Rd, Manchester M13 9PL, Lancs - England
[2] JEOL UK Ltd, Long Hanborough OX29 8SP - England
[3] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
[4] Inst Mat & Environm Chem, Res Ctr Nat Sci, Supramol Chem Res Grp, Eotvos Lorand Res Network ELKH, Magyar Tudosok Korutja 2, H-1117 Budapest - Hungary
Total Affiliations: 4
Document type: Journal article
Source: CHEMICAL SCIENCE; v. 12, n. 34 AUG 2021.
Web of Science Citations: 0
Abstract

Accurate measurement of transverse relaxation rates in coupled spin systems is important in the study of molecular dynamics, but is severely complicated by the signal modulations caused by scalar couplings in spin echo experiments. The most widely used experiments for measuring transverse relaxation in coupled systems, CPMG and PROJECT, can suppress such modulations, but they also both suppress some relaxation contributions, and average relaxation rates between coupled spins. Here we introduce a new experiment which for the first time allows accurate broadband measurement of transverse relaxation rates of coupled protons, and hence the determination of exchange rate constants in slow exchange from relaxation measurements. The problems encountered with existing methods are illustrated, and the use of the new method is demonstrated for the classic case of hindered amide rotation and for the more challenging problem of exchange between helical enantiomers of a gold(i) complex. (AU)

FAPESP's process: 18/19253-0 - NEW PULSE SEQUENCES AND PROCESSING TOOLS FOR MULTIDIMENSIONAL NMR EXPERIMENTS APPLIED TO NATURAL PRODUCTS MIXTURE ANALYSIS
Grantee:Guilherme Fonseca Dal Poggetto
Support Opportunities: Scholarships in Brazil - Post-Doctoral