Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women

Author(s):Show less -

Passos, Maria Elizabeth Pereira ^{[1, 2]} ; Borges, Leandro ^[1] ; dos Santos-Oliveira, Laiane Cristina ^[1] ; Alecrim-Zeza, Amanda Lins ^[1] ; Lobato, Tiago Bertola ^[1] ; de Oliveira, Heloisa Helena ^[1] ; Santos, Cesar Miguel Momesso ^[1] ; Diniz, Vinicius Leonardo Sousa ^[1] ; Iser-Bem, Patricia Nancy ^[1] ; Manoel, Richelieau ^[1] ; Murata, Gilson Masahiro ^[3] ; Hirabara, Sandro Massao ^[1] ; Curi, Rui ^{[4, 1]} ; Pithon-Curi, Tania Cristina ^[1] ; Hatanaka, Elaine ^[1] ; Gorjao, Renata ^[1]

Affiliation

^[1] Cruzeiro do Sul Univ, Interdisciplinary Program Hlth Sci, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Lab Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Clin Med, Fac Med, Sao Paulo - Brazil

^[4] Butantan Inst, Sao Paulo - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 42, n. 08, p. 749-759, JUN 2021.
• Web of Science Citations: 1

Abstract

This study aimed to investigate the impact of a 16-week dance-based aerobic exercise program on lymphocyte function in healthy and type 2 diabetes mellitus (T2DM) women. We enrolled 23 women: 11 with T2DM and 12 non-diabetic controls. Initially, we performed anthropometry and body composition measurements, afterwards, plasma levels of C-reactive protein, lipids, and glucose were determined. We used flow cytometry to measure the CD25 and CD28 expression in circulating lymphocytes, T-regulatory (Treg) cell percentage, lymphocyte proliferation, and cytokines released by cultured lymphocytes. The T2DM group had a lower proportion of CD28+ cells and a higher percentage of Treg lymphocytes and proliferative capacity at the baseline compared with the control group. After 16 weeks of the program, differences in lymphocytes between the T2DM and the control groups disappeared. The dance program promoted IL-10 increase in both groups. We found decreased IL-4, IL-2, and IL-6 secretion in lymphocytes from the control group and increased IL-17 secretion and IL-10/IL-17 ratio in the T2DM group after the program. The program promoted marked changes in lymphocytes in diabetic women, leading to a balance between the different profiles. (AU)

• FAPESP's process: 18/07283-1 - Effects of leptin on lymphocyte differentiation and metabolism
• Grantee: Renata Gorjao
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/21185-1 - Effect of moderate exercise training on inflammatory status and leukocyte functions in diabetic
• Grantee: Elaine Hatanaka Dermargos
• Support Opportunities: Regular Research Grants